This is a thorough revision and update of the highly successful first edition, which which achieved sales in excess of 4,500. The text serves as a comprehensive introduction to parasitology for both undergraduate and beginning graduate students. In this edition, particular emphasis is placed on parasites of human and veterinary importance. The first three chapters in the text are concerned with how parasites 'work, ' their biochemistry, molecular and cell biology and physiology. The remaining chapters cover ecology and epidemiology, immunology and chemotherapy, with the final chapter covering integrated control. This new edition contains new material on cell and molecular biology, vectors and control, which is in contrast to the general biological approach of the first edition. The second edition will succeed the first as the major text on parasitology for students in biology, zoology, microbiology, medicine, veterinary medicine, tropical medicine and public health

Neglected tropical diseases (NTDs) are a group of diseases frequently found in impoverished communities in tropical and sub-tropical countries. The risk for many of the NTDs is high in both deprived urban and rural areas of East Asia. Adapted to the endemic settings and characteristics of the diseases, a range of tools and strategies are currently being rolled out for the large-scale control of many NTDs. Both vector control measures and community sensitization programmes have for example been used to control dengue in urbanized settings. Challenges posed by yaws and lymphatic filariasis are being addressed by mass drug administration, while rabies requires the involvement of the veterinary public health sector for disease control. For leprosy, an elimination target has been defined; however, achieving this goal remains a considerable challenge. Food-borne trematodiases, on the other hand, are emerging and require a deeper understanding of its burden in East Asia and how these diseases can be tackled in a cost-effective manner. Finally, factors, such as an increase of non-communicable diseases due to changing lifestyles which accompany economic growth, the spreading HIV epidemic as well as climate change and the occurrence of natural disasters can potentially affect the epidemiology and control of NTDs. This volume discusses the mentioned topics in detail with contributions by experts in the respective research areas from different working environments.

The Plasmodium spp. parasite was identified as the causative agent of malaria in 1880, and the mosquito was identified as the vector in 1897. Despite subsequent efforts focused on the epidemiology, cell biology, immunology, molecular biology, and clinical manifestations of malaria and the Plasmodium parasite, there is still no licensed vaccine for the prevention of malaria. Physical barriers (bed nets, window screens) and chemical prevention methods (insecticides and mosquito repellents) intended to interfere with the transmission of the disease are not highly effective, and the profile of resistance of the parasite to chemoprophylactic and chemotherapeutic agents is increasing. The dawn of the new millennium has seen a resurgence of interest in the disease by government and philanthropic organizations, but we are still faced with compl- ities of the parasite, the host, and the vector, and the interactions among them. Malaria Methods and Protocols offers a comprehensive collection of protocols describing conventional and state-of-the-art techniques for the study of malaria, as well as associated theory and potential problems, written by experts in the field. The major themes reflected here include assessing the risk of infection and severity of disease, laboratory models, diagnosis and typing, molecular biology techniques, immunological techniques, cell biology techniques, and field applications.

In the first book of its kind, Helen J. Power uses the history of the Liverpool School of Tropical Medicine to explore the development of tropical medicine in Britain in the twentieth century. The contributors also consider the social, political, and economic forces that shape medicine and its application in the context of imperialism, independence, and postcolonial history. The Liverpool School of Tropical Medicine provides a unique framework for exploring the changes which took place as medicine progressed from being a tool of empire, to a form of social welfare, and finally to a basic human right.

Key Features: * Provides a comprehensive and complete resource on Leishmaniasis on various aspects of the disease, distilling credible information from available literature coupled with historical references. * Follows a model approach for handling emerging infectious diseases for the benefit of clinicians and front-line workers. * Discusses the unique problem of skin localizing visceral parasites and provides basic principles of management for other infectious diseases and vector-borne infections.

Despite vaccines and medicines, we have not succeeded in eradicating the most poisonous viruses in the world, like jaundice, measles, diarrhea, polio, and AIDS, not to mention newcomers like West Nile and SARS. Also, since September 11, it is no longer unthinkable that a terrorist would intentionally spread a virus among people or the food chain. In this book, Jaap Goudsmit argues that there is no such thing as life without viruses for many reasons; including the fact that many viruses spread without any visible signs, and can hide in animals; that there are too many different species of viruses and they multiply much faster than any animal or plant; and that infections strike especially in areas where life is difficult enough already, such as Africa and Asia.
However, Goudsmit continues, if viruses hold onto life so stubbornly, perhaps they can be useful to other living beings. Do viruses offer people a better chance of survival in a hostile world? Do viruses make people fitter? Some viruses seem to play a role in the process whereby our genes adapt to the environment. What is it that makes viruses incredibly strong, and can we learn something from it? What is the secret of the enormous "fitness" of viruses? Will viruses spell the end of mankind or will man always be able to offer resistance? This book attempts to answer these and other questions.

Based on papers presented at the XI International Congress for Tropical Medicine and Malaria, this publication provides an authoritative evaluation of treatment and control of helminth parasite infections. A section on leprosy and a brief review of malaria vaccination are included. A comprehensive review of the history of schistosomiasis control programs presents information unavailable elsewhere. This book is of special interest to professionals concerned with health problems of less developed countries and in particular to public health officials, epidemiologists and clinicians dealing with patients in or returning from the tropics.

On April 27th, 1994, the people of South Africa voted in their first democratic election, bringing down the curtain on 46 years of Apartheid. But, at the very moment of transition, the seeds of a grave epidemic had already been sown. AIDS has indelibly marked the era since the Apartheid's end, exacting an enormous toll on South Africa's Black community. Since the epidemic's onset, more thean 1,000,000 men, women and children have died. Shattered Dreams? is an oral history of how physicians and nurses in South Africa struggled to ride the tiger of the world's most catastrophic AIDS epidemic. Based on interviews - not only from the great urban centres of Johannesburg, Cape Town and Durban - but from provincial centres and rural villages, this book captures the experience of health care workers as they confronted indifference from colleagues, opposition from superiors, unexpected resistance from the country's political leaders, and material scarcity that was both the legacy of Apartheid and a consequence of the global power of the international pharmaceutical industry. In 2003, after years of bitter debate and persistent agitation on the part of treatment activists, the national government committed itself to making anti-retroviral drugs available to those whose lives hung in the balance. Now that a halting rollout of drug treatment has begun, it is more crucial than ever to capture the experiences of those who, as caregivers, have been witness to the unfolding South African epidemic and who are now able to provide these new medications to a small but growing number of their patients.

The first in a new series created to acknowledge the explosion of knowledge in fields related to infectious disesases and clinical microbiology. Thirteen contributions focus on organisms which are of major medical importance in this country or which have contributed to an understanding of pathology.

Today's travel medicine includes not only tourism and business travelers, but also incorporates volunteerism, medical care, migration, ecotourism, and more. Travel Medicine, 4th Edition, reflects all of these changes in the field while keeping you up to date with new vaccines and newly proposed regimens, pre-travel advice and post-travel screening, and all travel-related illnesses - for a one-stop, authoritative reference on all aspects of travel medicine. Includes new chapters to assist your care of specific populations such as those engaging in ecotourism or military travel, as well as the VIP traveler. A new chapter on pre-travel considerations for non-vaccine preventable travel infections has also been added. Provides new information on new influenza and shingles vaccines, microbiome and drug resistance, Zika and the pregnant or breastfeeding traveler, the Viagra effect and increase in STIs, refugees and immigrants, and much more. Covers new methods of prevention of dengue virus, Zika virus, chikungunya virus, Middle Eastern respiratory syndrome, sleeping sickness, and avian flu. New illustrations and numerous new tables and boxes provide visual guidance and make reference quick and easy. Helps you prepare for the travel medicine examination with convenient cross references to the ISTM "body of knowledge" in specific chapters and/or passages in the book. Keeps you updated on remote destinations and the unique perils they present. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Venom research and technology has advanced greatly, rapidly transforming the area of reptile venom. Research developments-like the development of molecular systematics-provide the framework necessary to reconstruct the evolutionary history of glands and fangs. Such research developments result in a fundamental shift in scientists' understanding of venom's evolution and usefulness in therapeutic development. Startling evolutionary expansion, including the development of new protein functions, enable the development of novel drug therapies and impact the effectiveness of anti-venoms available for the treatment of humans. Venomous Reptiles And Their Toxins is a comprehensive study of the entire scope of reptile venom, from its evolution to drug design and development. This book devotes a chapter to each toxin class found in reptile venom, detailing the full trajectory of research on the toxin in question. The comprehensive synthesis of research deals with the impact that venom has had on biomedical applications and snake evolution and ecology.

Offering an example for transnational cooperation and successful reduction of a neglected tropical disease, this volume shows how Chinese scientists and local physicians controlled schistosomiasis in Zanzibar. Over a four-year study, local medical specialists and the population of Zanzibar were taught how to diagnose the parasitosis caused by flukes (trematode worms) of the genus Schistosoma. Furthermore, methods to eliminate the disease and prevent new infections were established. The developed control system will avoid repeated increase of human schistosomiasis, which is still prevalent in the tropics and subtropics. Rural populations and poor communities lacking access to clean drinking water and adequate sanitation are most affected. This book is a blueprint of activities urgently needed to combat schistosomiasis in countries with low medical impact. The strategies outlined are particularly relevant to parasitologists and professionals in public health, physicians, medical personnel and also governmental, healthcare and pharmaceutical institutions.

This volume of the Neglected Tropical Diseases (NTD) series covers the most prevalent NTDs in North America. This book discusses in detail pathology, diagnostics and control approaches of selected NTDs in the sub-tropical regions of the United States of America. There are disproportionate numbers of children and adults living in poverty within the United States that are at risk of infections caused by helminths, protozoa, viruses and bacteria which commonly lead to chronic, debilitating and stigmatizing diseases. Each chapter focuses on one specific disease or series of related diseases, and provides in-depth insights into the topic.

An Open Access edition of this book is available on the Liverpool University Press website and the OAPEN library. Colonialism created exclusive economic and segregatory social spaces for the exploitation and management of natural and human resources, in the form of plantations, ports, mining towns, hill stations, civil lines and new urban centres for Europeans. Contagion and Enclaves studies the social history of medicine within two intersecting enclaves in colonial India; the hill station of Darjeeling which incorporated the sanitarian and racial norms of the British Raj; and in the adjacent tea plantations of North Bengal, which produced tea for the global market. This book studies the demographic and environmental transformation of the region: the racialization of urban spaces and its contestations, establishment of hill sanatoria, expansion of tea cultivation, labour emigration and the paternalistic modes of healthcare in the plantation. It examines how the threat of epidemics and riots informed the conflictual relationship between the plantations with the adjacent agricultural villages and district towns. It reveals how Tropical Medicine was practised in its 'field'; researches in malaria, hookworm, dysentery, cholera and leprosy were informed by investigations here, and the exigencies of the colonial state, private entrepreneurship, and municipal governance subverted their implementation. Contagion and Enclaves establishes the vital link between medicine, the political economy and the social history of colonialism. It demonstrates that while enclaves were essential and distinctive sites of articulation of colonial power and economy, they were not isolated sites. The book shows that the critical aspect of the enclaves was in their interconnectedness; with other enclaves, with the global economy and international medical research.

This thematic collection focuses on key parasites and their vectors in Southeast Asia. Up-to-date essays invite readers to discover parasite and vector morphology, genetic diversity as well as dynamic parasite communities linked to human land-use and climate change. The authors shed light on transmission pathways and explore tick-borne diseases, intestinal protozoa, cestodes, nematodes and the multiplicity of cryptic trematode species. Particular attention is given to mosquito vectors in changing environments and the dynamic biodiversity of vertebrate hosts, including mammals, birds and fish. The richly illustrated chapters are completed by new approaches in diagnostic methods, treatment and prevention to protect humans and animals from tropical parasite infections. Not only parasitologists and experts in tropical medicine but also public health officials and travelers will find this volume highly informative.

Over the years, Oxfam has been involved in a wide variety of health-related projects. The Practical Health Guides draw on this experience to put forward ideas on best practice in the provision of health care and services in developing countries The number of refugees and displaced persons has increased greatly in recent years. At least 80 per cent of them are living in tropical or semi-tropical countries where vector-borne diseases, such as malaria, dengue fever and sleeping sickness are common and cause widespread sickness and death in the crowded conditions of refugee camps. This work is intended to help development workers and planners to identify and assess the risks of vector-borne diseases in a camp and to plan and implement cost-effective ways of controlling them. The main vector-borne diseases are described, the importance of identifying the particular disease and its vector and of considering a variety of methods of control is emphasized. The book discusses the need for a community-based approach to vector control, the safe use of insecticides and selection of spraying equipment. Also included are lists of suppliers of insecticides and equipment, sources of advice and recommended texts.

The Oxford Handbook of Tropical Medicine, fifth edition is the definitive resource for medical problems in tropical regions, and in low-resource settings. Comprehensive in scope, and concise in style, this portable guide ensures that you always have the vital information you need at your fingertips. Fully revised and updated for its fifth edition, it is now even better than ever. The chapter on HIV medicine has been significantly updated, and other revisions include up-to-date guidance on viruses such as COVID-19 and Ebola, improved vaccine regimens, and rabies prophylaxis. With the clear, easy-reference style of the trusted Oxford Handbook format, written and reviewed by an international team of clinical experts, this is a truly global handbook and an essential resource. Make sure you never leave home without it!

This is the first comprehensive review of the world literature on filovirus research and provides the most extensive bibliography of the subject yet published. There is special emphasis on foreign literature that has never been summarized. Every aspect of filovirus research, including their history, epidemiology, clinical picture, pathology, molecular biology, and political aspects are reviewed in detail.

Plasmodium falciparum malaria is responsible for the deaths of nearly 500,000 people each year. Much attention has been paid to antibody and cellular mechanisms of immunity against this pathogen. By contrast, the role that the complement system plays in immunity and pathogenesis in this infection is not very well recognized or understood. Based on the work of a number of research groups, we know that complement plays an important role in these processes. In this book, some of the leading scientists in the field discuss the mechanisms of complement activation during malaria infection as well as the role of complement in the pathogenesis of key syndromes such as severe malarial anemia, cerebral malaria, and placental malaria. In addition, they review recently-identified complement evasion strategies of P. falciparum merozoites, and how these mechanisms may translate into paradoxical enhancement of infection rather than protection. Finally, they also discuss the role of the mosquito complement system on immunity against the parasite.

In this second edition of Infectious Diseases and Arthropods, Jerome Goddard summarizes the latest thinking about the biological, entomological, and clinical aspects of the major vector-borne diseases around the world. His book covers mosquito-, tick-, and flea-borne diseases, and a variety of other miscellaneous vector-borne diseases, including Chagas' disease, African sleeping sickness, onchocerciasis, scrub typhus, and louse-borne infections. The author provides for each disease a description of the vector involved, notes on its biology and ecology, distribution maps, and general clinical guidelines for treatment and control. Among the diseases fully discussed are malaria, dengue and yellow fevers, lymphatic filariasis, spotted fevers, ehrlichiosis, lyme disease, tularemia, and plague. Other arthropod-caused or related problems-such as myiasis, imaginary insect or mite infestations, and arthropod stings and bites-are also treated.
At a time when vector-borne diseases are spreading ever more widely, Infectious Diseases and Arthropods provides physicians, infectious disease specialists, medical entomologists, and public health officials with an up-to-date, readily accessible, gold-standard reference source.

This book addresses the major neglected tropical diseases (NTDs) – based on their prevalence and the years of healthy life lost to disability – in Latin American and Caribbean countries. These include Chagas disease, leishmaniasis, hookworm infection, and other soil-transmitted helminth infections, followed by dengue, schistosomiasis, leishmaniasis, leprosy, cysticercosis, bartonellosis, Plasmodium vivax malaria, and onchocerciasis. Topics like disease burden, major manifestations and approaches to the control and elimination of NTDs in Latin America and the Caribbean are discussed in detail. As such, the book will be of general interest to basic researchers and clinicians engaged in infectious disease, tropical medicine, and parasitology, and a must-have for scientists specialized in the characteristics of this region of the world.​

This fully updated third edition of a classic book, widely cited as the most important and useful volume for health engineering and disease prevention, describes infectious diseases in tropical and developing countries, and the measures that may be used effectively against them. The infections described include the diarrheal diseases, the common gut worms, guinea worm, schistosomiasis, malaria, bancroftian filariasis, and other mosquito borne infections. The environmental interventions that receive most attention are domestic water supplies and improved excreta disposal. Appropriate technology for these interventions, and also their impact on infectious diseases are documented in detail.This edition includes new sections on arsenic in groundwater supplies and arsenic removal technologies as well as new material in most chapters, including information on water supplies in developing countries and surface water drainage.

This book intensively examines the efficacy of plant-derived products that have been used for over a thousand years by practitioners of so-called Traditional Chinese Medicine in the light of recent chemotherapeuticals. The chapters were written by renowned Chinese medical researchers and are supplemented by results obtained in German antiparasitic research projects. Parasites and emerging diseases are a major threat of our time, which is characterized by an enormous increase in the size of the human population and by an unbelievably rapid globalization that has led to the daily transport of millions of humans and containers with goods from one end of the earth to the other. Furthermore the slow but constant global warming offers new opportunities for many agents of diseases to become established in new areas. Therefore it is essential that we develop precautions in order to avoid epidemics or even pandemics in overcrowded megacities or at the large-scale farm animal confinements that are needed to secure a steady flow of food in the crowded regions of the world. Of course intensive research in the field of chemotherapy since 1900 has produced unbelievable breakthroughs in therapies for formerly untreatable and thus deadly diseases. However, a large number of untreatable diseases remain, as well as a constantly growing number of agents of disease that have developed resistances to standard chemical compounds. As such, it is not only worthwhile but also vital to consider the enormous amounts of information that have been obtained by human "high cultures" in the past. Examples from the past (like quinine) or present (like artemisinin, a modern antimalarial drug) show that plant extracts may hold tremendous potential in the fight against parasites and/or against vector-transmitted agents of diseases.

The Middle East and North Africa (MENA) is highly endemic for several neglected tropical diseases (NTDs), including viral, bacterial, protozoan and helminth infections. This new volume covers the most prevalent NTDs found in about 22 MENA countries emphasizing the disease burden, clinical manifestations and control approaches. Each individual chapter deals with one specific disease and is written by a group of experts on that topic.

The most feared attribute of the human pathogen Vibrio cholerae is its ability to cause outbreaks that spread like wildfire, completely overwhelming public health systems and causing widespread suffering and death. This volume starts with a description of the contrasting patterns of outbreaks caused by the classical and El Tor biotypes of V. cholerae. Subsequent chapters examine cholera outbreaks in detail, including possible sources of infection and molecular epidemiology on three different continents, the emergence of new clones through the bactericidal selection process of lytic cholera phages, the circulation and transmission of clones of the pathogen during outbreaks and novel approaches to modeling cholera outbreaks. A further contribution deals with the application of the genomic sciences to trace the spread of cholera epidemics and how this information can be used to control cholera outbreaks. The book closes with an analysis of the potential use of killed oral cholera vaccines to stop the spread of cholera outbreaks.