Neglected Diseases: Extensive Space for Modern Drug Discovery provides in-depth reviews on the last progresses about neglected tropical diseases research. Topics covered in this volume include Leishmaniasis, Tripanosomiasis, Onchocerciasis and Ebolavirus infections, with insights on the future of the research on them. Part of the volume is devoted to recent contributions this field received from X-Ray crystallography.

Climate change and environmental pollution remain two primary areas of concern in today's world. These detrimental influences continue to have a strong impact on various aspects of humanity, specifically public health in tropical regions. Researchers have seen neglected tropical diseases (NTDs) affected by climate change and anthropogenic impacts. Climate Change and Anthropogenic Impacts on Neglected Tropical Diseases is a pivotal reference source that provides vital research on the association of environmental pollutants and global warming with viruses in tropical regions. While highlighting topics such as pathogenicity, travel impact, and economic impacts, this publication explores the developments and trends in these areas of medicine and ecology, as well as prevention strategies to be used for educational and sensitization purposes. This book is ideally designed for doctors, medical practitioners, ecologists, epidemiologists, environmentalists, world health organizations, researchers, biologists, policymakers, academicians, and students.

Travel health nursing has evolved as a distinct and increasingly complex specialty over the past three decades, and in 2020, ANA officially recognized travel health nursing as a nursing specialty for the first time. This first edition of ANA and ATHNA's Travel Health Nursing: Scope and Standards of Practice is an important professional resource for nurses who strive to advance the well-being of all domestic and international travellers, and the communities to which they travel and return. Travel health nurses are specially educated and trained to promote the health and safety of travellers through comprehensive risk analysis, assessment, immunizations, health education, and therapeutic interventions. Nurses in this specialty provide services in three different clinical encounters: pre-travel, during travel ("in-transit"), and post-travel in a variety of settings that include college health, occupational health, public health, the military, primary care, and nurse-managed travel health clinics, among others.

This new edition describes the role of heat shock proteins in the life cycle of malaria parasites, particularly in the context of intracellular parasite stages. Thoroughly revised, this work provides a general introduction to the structural and functional features of heat shock proteins with a special focus on their role as molecular chaperones in ensuring protein quality control. The emphasis is on the heat shock protein families from Plasmodium falciparum, and their role in proteostasis and the development of malaria pathology. Moreover, the authors explore the latest prospects of targeting heat shock proteins in antimalarial drug discovery either directly or in combination therapies. Readers will experience a functional analysis of the individual families of heat shock proteins and their cooperation in functional networks, including both the parasite-resident proteome and the exportome released into host cells during intracellular stages. Subcellular and extracellular organelles such as the apicoplast and the Maurer's Clefts associated with Plasmodium species are discussed in detail. The book highlights the role of heat shock proteins in the development and function of these structures. Biochemical expertise and the inclusion of novel therapeutic solutions make this collection a unique reference for experts in heat shock protein research, parasitology and infectious diseases, cell stress, molecular biology and drug discovery. Not least, advances in malaria control will contribute to ending epidemics and ensuring healthy lives in line with the UN Sustainable Development Goals.

Applications of Nanobiotechnology for Neglected Tropical Diseases describes recent advances in nanobiotechnology that can be applied to reducing the global disease burden of neglected tropical diseases (NTDs). The book explores the application of nanotechnology on the development of safe, effective, and reliable tools to prevent, diagnose, and treat NTDs. Furthermore, Applications of Nanobiotechnology for Neglected Tropical Diseases includes multidisciplinary content, combining knowledge from biochemistry, medicinal chemistry, material sciences, pharmacology, and pharmaceutics. The book is divided into three main parts, each outlining one major type of approach: (1) nano-based approaches for prevention, (2) nano-diagnostics and detection, and (3) nanotherapeutics. Each part contains chapters that delve into the different applications of the type of approach being presented in that part. A discussion of other approaches against NTD follows these three parts. This book is remarkable in its ability to encompass and thoroughly explain the latest techniques in nanobiotechnology, from basic research to patient-oriented investigation.

Cook explores the development of clinical tropical medicine from the 19th century onwards by following the pioneering doctors in this discipline, their personalities, achievements and scientific breakthroughs.

This thematic collection focuses on key parasites and their vectors in Southeast Asia. Up-to-date essays invite readers to discover parasite and vector morphology, genetic diversity as well as dynamic parasite communities linked to human land-use and climate change. The authors shed light on transmission pathways and explore tick-borne diseases, intestinal protozoa, cestodes, nematodes and the multiplicity of cryptic trematode species. Particular attention is given to mosquito vectors in changing environments and the dynamic biodiversity of vertebrate hosts, including mammals, birds and fish. The richly illustrated chapters are completed by new approaches in diagnostic methods, treatment and prevention to protect humans and animals from tropical parasite infections. Not only parasitologists and experts in tropical medicine but also public health officials and travelers will find this volume highly informative.

Mosquitoes, Communities, and Public Health in Texas focuses on 87 known species of mosquitoes found throughout Texas. It includes information on the ecology, medical and public health importance, and biological diversity of each species. In addition, it provides detailed identification keys for both larval and adult stages of all mosquito genera and species known to occur in Texas, along a review of surveillance and control strategies. The expansion of invasive mosquitoes from other regions (including Mexico), together with climate change occurrences increase the likelihood for an increase in diseases, such as West Nile Virus, Yellow Fever, Dengue, Chikungunya and Zika. This unique work is the first unified reference and resource rich in mosquito information for medical entomologists, mosquito and vector control professionals, pest management professionals, biologists, environmentalists, wildlife professionals, government regulators, instructors of medical entomology and public health professionals who have disease or vector responsibilities, mosquito taxonomists, epidemiologists, entomology students, academia, pest control industry, and libraries, etc., with utility for medical, veterinary and health professionals.

Offering an example for transnational cooperation and successful reduction of a neglected tropical disease, this volume shows how Chinese scientists and local physicians controlled schistosomiasis in Zanzibar. Over a four-year study, local medical specialists and the population of Zanzibar were taught how to diagnose the parasitosis caused by flukes (trematode worms) of the genus Schistosoma. Furthermore, methods to eliminate the disease and prevent new infections were established. The developed control system will avoid repeated increase of human schistosomiasis, which is still prevalent in the tropics and subtropics. Rural populations and poor communities lacking access to clean drinking water and adequate sanitation are most affected. This book is a blueprint of activities urgently needed to combat schistosomiasis in countries with low medical impact. The strategies outlined are particularly relevant to parasitologists and professionals in public health, physicians, medical personnel and also governmental, healthcare and pharmaceutical institutions.

This book presents a comprehensive and up to date account of the chemotherapy of parasitic diseases, both human and veterinary. The book starts with an overview of parasitic diseases. The body of the book is divided into two parts: antihelminthic drugs, and antiprotozoal drugs. Both parts start with chapters highlighting the 'biochemical targets' available for chemotherapeutic interference. Individual chapters deal with one chemical class of compounds and describe their origin, structure-activity relationship, mode of action, and methods of synthesis and their status both in clinical and veterinary practice. The book will be useful to a wide spectrum of readers: students embarking on a research career in parasitic chemotherapy, clinicians (and veterinarians) and clinical pharmacologists desiring detailed information about the drugs currently in use, and pharmaceutical technologists wanting to update their knowledge of the methods of manufacture.

Plasmodium falciparum malaria is responsible for the deaths of nearly 500,000 people each year. Much attention has been paid to antibody and cellular mechanisms of immunity against this pathogen. By contrast, the role that the complement system plays in immunity and pathogenesis in this infection is not very well recognized or understood. Based on the work of a number of research groups, we know that complement plays an important role in these processes. In this book, some of the leading scientists in the field discuss the mechanisms of complement activation during malaria infection as well as the role of complement in the pathogenesis of key syndromes such as severe malarial anemia, cerebral malaria, and placental malaria. In addition, they review recently-identified complement evasion strategies of P. falciparum merozoites, and how these mechanisms may translate into paradoxical enhancement of infection rather than protection. Finally, they also discuss the role of the mosquito complement system on immunity against the parasite.

This book reviews the current strategies and challenges for the treatment of bacterial, fungal, parasitic and viral infectious diseases in developing countries. Contributing authors present expert analysis on the transmission, epidemiology, bacteriology, pathogenesis and treatment of Neglected Tropical Bacterial Diseases such as Leprosy, Buruli ulcer, and Trachoma. Particular attention is also given to current antifungal agents, their spectrum of activity, mode of action, limitations, and current challenges in antifungal therapy. The authors explore the medicinal chemistry efforts that gave rise to currently launched drugs and new anti-HIV agents, and they also highlight the latest vaccine and drug developments in the clinical management of the Ebola Virus Disease, ignited by the 2014-2016 outbreak. This work has an interdisciplinary appeal and will engage scholars and professionals in the burden of communicable diseases.

This volume of the Neglected Tropical Diseases (NTD) series covers the most prevalent NTDs in Europe and Central Asia. This book discusses in detail the pathology, diagnostics and control approaches of the most important neglected pathogens occurring in these geographical regions. Each chapter focuses on one specific disease or group of related diseases, and provides the reader with in-depth insights into the topic. This volume addresses researchers in Microbiology and Biomedicine as well as clinicians and public health officials working in affected regions.

Natural Products in Vector-Borne Disease Management explores the potential application of natural products in vector control and disease management. The chapters discuss the global impact of specific vector-borne diseases, gaps in management, and natural products in specific stages of development - discovery, optimization, validation, and preclinical/clinical development. Toxic effects and mechanisms of action are also discussed. This book also explores how therapeutic plant derivatives can be used to combat the vectors of infection and how natural products can be used to manage and treat vector-borne diseases like malaria, leishmaniasis, dengue, and trypanosomiasis. With the inclusion of case studies on field and clinical applications and the contributions from experts in the field, Natural Products in Vector-Borne Disease Management is an essential resource to researchers, academics, and clinicians in parasitology, virology, microbiology, biotechnology, pharmacology, and pharmacognosy working in the field of vector-borne diseases.

This third edition is expanded, revised and largely re-written. However the aim remains the same and it is hoped that anyone involved in Travel or Tropical Medicine will find the contents interesting, stimulating and helpful.

As before it is divided into easy-to-read sections with clear answers that sometimes encapsulate whole diseases.

The four-part question format is retained in order to aid those intending to take Certificate or other exams in Travel Medicine. The correct answer to each question is that which is generally accepted as the best one. Nonetheless the reader may quibble with some answers and the author is always happy to accept sound advice and change accordingly.

Travel Medicine has a broad canvas. It cuts across the boundaries of Infectious Diseases, Internal Medicine, Tropical Medicine, Geographical Medicine, Aviation and Refugee Medicine. Because of this the few Textbooks we have Travel Medicine are large and difficult to digest.

This little book attempts to set down in concise form the essential elements of Travel Medicine in a way that is easy to read yet challenging.

These pages certainly invite the reader to share in excitement and wonder of this fascinating subject.

Mir S. Mulla joined the faculty of the Entomology Department at the University of California, Riverside in 1956, only two years after the Riverside campus was established as an independent campus within the University of California system. Prior to his appointment, Mir received his B.S. from Cornell University and then moved to the University of California, Berkeley to pursue his graduate studies. His Ph.D. from Berkeley, awarded in 1955, completed his formal American education which was the purpose of his immigration from his native Kandahar in Afghanistan. In his over 50 years at Riverside, Mir has made an incalculable impact on vector biology both within the United States and in developing countries throughout the world. Within Southern California, Mir's basic and applied research led to the rapid and sustainable control of mosquitoes and eye gnats in the Coachella Valley and so directly enabled this region to grow to the thriving, large community it is today. In 2006 his efforts in facilitating the development of the low desert of southern California were recognized through the dedication of the Mir S. Mulla Biological Control Facility by the Coachella Valley Mosquito and Vector Control District. His success has been so profound that it remains somewhat cryptic to the many who now reside in, visit, and enjoy, this region of California, oblivious to the insect problems that severely restrained development until Mir and his students ?rst applied their expertise many decades ago.

This comprehensive review provides a systematic, unbiased analysis, critique and summary of the available literature and generates novel clinical decision-making algorithms which can aid clinicians and scientists in practice management and research development. Potential mechanisms for the identified drug interactions are deduced from available preclinical and in vitro data which are interpreted in the context of the in vivo findings. Current limitations and gaps in the literature are summarized, and potential future research directions / experimentations are also suggested. In addition to the main objective to review the available clinical pharmacokinetic and pharmacodynamic drug interactions associated with WHO-recommended antimalarial drugs on the market today (i.e. chloroquine, amodiaquine, sulfadoxine, pyrimethamine, mefloquine, artemisinin, artemether, artesunate, dihydroartemisinin, artemotil, lumefantrine, primaquine, atovaquone, proguanil, piperaquine and quinine), this book also provides succinct chapter summaries on the epidemiology of malaria infection, diagnosis and therapeutics, in vivo pharmacology and chemistry, preclinical pharmacology, in vitro pharmacodynamics, in vitro reaction phenotyping, and in vitro drug-drug interaction data associated with the identified antimalarial drugs.

This book addresses the major neglected tropical diseases (NTDs) - based on their prevalence and the years of healthy life lost to disability - in Latin American and Caribbean countries. These include Chagas disease, leishmaniasis, hookworm infection, and other soil-transmitted helminth infections, followed by dengue, schistosomiasis, leishmaniasis, leprosy, cysticercosis, bartonellosis, Plasmodium vivax malaria, and onchocerciasis. Topics like disease burden, major manifestations and approaches to the control and elimination of NTDs in Latin America and the Caribbean are discussed in detail. As such, the book will be of general interest to basic researchers and clinicians engaged in infectious disease, tropical medicine, and parasitology, and a must-have for scientists specialized in the characteristics of this region of the world.

This book intensively examines the efficacy of plant-derived products that have been used for over a thousand years by practitioners of so-called Traditional Chinese Medicine in the light of recent chemotherapeuticals. The chapters were written by renowned Chinese medical researchers and are supplemented by results obtained in German antiparasitic research projects. Parasites and emerging diseases are a major threat of our time, which is characterized by an enormous increase in the size of the human population and by an unbelievably rapid globalization that has led to the daily transport of millions of humans and containers with goods from one end of the earth to the other. Furthermore the slow but constant global warming offers new opportunities for many agents of diseases to become established in new areas. Therefore it is essential that we develop precautions in order to avoid epidemics or even pandemics in overcrowded megacities or at the large-scale farm animal confinements that are needed to secure a steady flow of food in the crowded regions of the world. Of course intensive research in the field of chemotherapy since 1900 has produced unbelievable breakthroughs in therapies for formerly untreatable and thus deadly diseases. However, a large number of untreatable diseases remain, as well as a constantly growing number of agents of disease that have developed resistances to standard chemical compounds. As such, it is not only worthwhile but also vital to consider the enormous amounts of information that have been obtained by human "high cultures" in the past. Examples from the past (like quinine) or present (like artemisinin, a modern antimalarial drug) show that plant extracts may hold tremendous potential in the fight against parasites and/or against vector-transmitted agents of diseases.