Neglected tropical diseases (NTDs) are a group of diseases frequently found in impoverished communities in tropical and sub-tropical countries. The risk for many of the NTDs is high in both deprived urban and rural areas of East Asia. Adapted to the endemic settings and characteristics of the diseases, a range of tools and strategies are currently being rolled out for the large-scale control of many NTDs. Both vector control measures and community sensitization programmes have for example been used to control dengue in urbanized settings. Challenges posed by yaws and lymphatic filariasis are being addressed by mass drug administration, while rabies requires the involvement of the veterinary public health sector for disease control. For leprosy, an elimination target has been defined; however, achieving this goal remains a considerable challenge. Food-borne trematodiases, on the other hand, are emerging and require a deeper understanding of its burden in East Asia and how these diseases can be tackled in a cost-effective manner. Finally, factors, such as an increase of non-communicable diseases due to changing lifestyles which accompany economic growth, the spreading HIV epidemic as well as climate change and the occurrence of natural disasters can potentially affect the epidemiology and control of NTDs. This volume discusses the mentioned topics in detail with contributions by experts in the respective research areas from different working environments.

Chikungunya (CHIKV) is a viral infection spread by mosquitoes that can cause symptoms such as fever, joint pain, muscle pain, headache, fatigue, and rash, which can become severe. While symptoms generally subside within a week or two, the disease nonetheless imposes a burden on societies around the world and carries a death risk of 1 in 1,000 infections. Chapter One details the history and evolution of the virus, including its epidemiology and extensive spread, and discusses disease prevention and vector control measures. Chapter Two describes the geographical distribution, transmission, and alternative hosts of Chikungunya. Chapter Three provides an insight into the different immunotherapy and immunoprophylaxis strategies that have demonstrated promising results so far for the treatment of this disease. Lastly, Chapter Four provides an overview of the potential therapeutics that have been proposed and developed for CHIKV.

With the exception of a few tropical medicine schools worldwide, current medical education programs include almost zero discussion of the interface between infectious diseases and entomology. That is why this book was initially published in the first edition almost 17 years ago. The third edition of this valuable infectious disease entomology book updates all existing chapters with the newest scientific developments described in the medical and entomological literature in addition to covering 10 entirely new topics not addressed in previous editions, which include: * arthropod identification controversies * early beginnings of public health and disease control * red-meat allergy * updates on vaccine development for dengue and malaria * discussion of Chikungunya and Zika viruses * American Boutonnneuse Fever * the newest controversies in Lyme disease * recent findings of viruses in ticks * bed bug bite reactions * Morgellons disease (an imaginary infectious disease)

This second edition of the popular advanced student textbook (previously published as "Worms and Disease: A Manual of Medical Helminthology") has been thoroughly updated and revised since it was first published in 1975. It includes contributions and a chapter by Prof. Derek Wakelin, University of Nottingham, UK. * An authoritative handbook covering all human helminth infections with particular emphasis on diagnosis, treatment, clinical manifestations, pathogenesis, epidemiology and control * Practical guidelines are given for estimating the clinical and public significance of helminthiases, vital in areas where the majority of inhabitants are infected with many helminths but only a few are sick.

This comprehensive review provides a systematic, unbiased analysis, critique and summary of the available literature and generates novel clinical decision-making algorithms which can aid clinicians and scientists in practice management and research development. Potential mechanisms for the identified drug interactions are deduced from available preclinical and in vitro data which are interpreted in the context of the in vivo findings. Current limitations and gaps in the literature are summarized, and potential future research directions / experimentations are also suggested. In addition to the main objective to review the available clinical pharmacokinetic and pharmacodynamic drug interactions associated with WHO-recommended antimalarial drugs on the market today (i.e. chloroquine, amodiaquine, sulfadoxine, pyrimethamine, mefloquine, artemisinin, artemether, artesunate, dihydroartemisinin, artemotil, lumefantrine, primaquine, atovaquone, proguanil, piperaquine and quinine), this book also provides succinct chapter summaries on the epidemiology of malaria infection, diagnosis and therapeutics, in vivo pharmacology and chemistry, preclinical pharmacology, in vitro pharmacodynamics, in vitro reaction phenotyping, and in vitro drug-drug interaction data associated with the identified antimalarial drugs.

African trypanosomes are tsetse-transmitted protozoa that inhabit the extracellular compartment of host blood. They cause fatal sleeping sickness in people, and Nagana, a wasting and generally fatal disease, in cattle. While trypanosomes are most common to Africa (about 30% of Africa's cattle graze on the fringe of the tsetse habitat), some species have spread beyond its boarders to Asia, the Middle East and South America. The African Trypanosomes, volume one of World Class Parasites, is written for researchers, students and scholars who enjoy reading research that has a major impact on human health, or agricultural productivity, and against which we have no satisfactory defense. It is intended to supplement more formal texts that cover taxonomy, life cycles, morphology, vector distribution, symptoms and treatment. It integrates vector, pathogen and host biology and celebrates the diversity of approach that comprises modern parasitological research.

It is almost twenty years ago since under Nutricia's auspices the first Nutricia Symposium took place. Professor Jonxis was mainly responsible for the organiza tion of the earlier symposia, whilst Professor Visser organized the fifth Nutricia Symposium in 1978. This book is the commitment to paper of the lectures given during the sixth Nutricia/Cow & Gate Symposium held in Louvain in 1983. Both Professor Eeckels and Professor Ransome-Kuti succeeded in collecting a panel of experts on 'Child Health in the Tropics'. We hope, in fact we are sure, that you will consider the contents of this book a daily stimulation in your medical profession. October 1984 Contents Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . V List of authors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . XI List of participants. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . XIV SESSION I FEEDING, FEEDING PRACTICES AND GROWTH Chairman: Chap-Yung Yeung A. Omololu, The practice of breastfeeding . . . . . . . . . . . . . . . . . . . . . . . . . . 3 M. G. M. Rowland, S. G. l. Goh, S. Tullock, D. T. Dunn and R. l. Hayes, Growth and weaning in urban Gambian infants. . . . . . . . . . . . . . . . . . . . 9 W. Klaver, Some considerations on the formulation of weaning mixes. . 19 R. G. Hendrickse, The influence of mycotoxins on child health in the tropics. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29 V. S. Tanphaichitr, C. Tuchinda, V. Suvatte and S. Tuchinda, Bodily growth in thalassemia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43 L. Sinisterra, Ecological evaluation of human development: the case of the child in the tropics. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51 SESSION II DIARRHOEAL DISEASES Chairman: o. Ransome-Kuti A. M. Molla, S. A. Sarker, A. Molla, M. Kathoon, W. B."

"Networks in Tropical Medicine" explores how European doctors and scientists worked together across borders to establish the new field of tropical medicine in the late nineteenth and early twentieth centuries. The book shows that this transnational collaboration in a context of European colonialism, scientific discovery, and internationalism shaped the character of the new medical specialty. Even in an era of intense competition among European states, practitioners of tropical medicine created a transnational scientific community through which they influenced each other and the health care that was introduced to the tropical world. One of the most important developments in the shaping of tropical medicine as a specialty was the major sleeping sickness epidemic that spread across sub-Saharan Africa at the turn of the century. The book describes how scientists and doctors collaborated across borders to control, contain, and find a treatment for the disease. It demonstrates that these medical specialists' shared notions of "Europeanness," rooted in common beliefs about scientific, technological, and racial superiority, led them to establish a colonial medical practice in Africa that sometimes oppressed the same people it was created to help.

In this second edition of Infectious Diseases and Arthropods, Jerome Goddard summarizes the latest thinking about the biological, entomological, and clinical aspects of the major vector-borne diseases around the world. His book covers mosquito-, tick-, and flea-borne diseases, and a variety of other miscellaneous vector-borne diseases, including Chagas' disease, African sleeping sickness, onchocerciasis, scrub typhus, and louse-borne infections. The author provides for each disease a description of the vector involved, notes on its biology and ecology, distribution maps, and general clinical guidelines for treatment and control. Among the diseases fully discussed are malaria, dengue and yellow fevers, lymphatic filariasis, spotted fevers, ehrlichiosis, lyme disease, tularemia, and plague. Other arthropod-caused or related problems-such as myiasis, imaginary insect or mite infestations, and arthropod stings and bites-are also treated.
At a time when vector-borne diseases are spreading ever more widely, Infectious Diseases and Arthropods provides physicians, infectious disease specialists, medical entomologists, and public health officials with an up-to-date, readily accessible, gold-standard reference source.

Natural Products in Vector-Borne Disease Management explores the potential application of natural products in vector control and disease management. The chapters discuss the global impact of specific vector-borne diseases, gaps in management, and natural products in specific stages of development - discovery, optimization, validation, and preclinical/clinical development. Toxic effects and mechanisms of action are also discussed. This book also explores how therapeutic plant derivatives can be used to combat the vectors of infection and how natural products can be used to manage and treat vector-borne diseases like malaria, leishmaniasis, dengue, and trypanosomiasis. With the inclusion of case studies on field and clinical applications and the contributions from experts in the field, Natural Products in Vector-Borne Disease Management is an essential resource to researchers, academics, and clinicians in parasitology, virology, microbiology, biotechnology, pharmacology, and pharmacognosy working in the field of vector-borne diseases.

Tropical diseases remain a major global concern, not only because they affect a huge part of the world population, but also because of the growing global movement of people associated with employment, tourism, and war. Recent advances in molecular biology, epitomized by the genomic revolution, have brought new promises of powerful scientific approaches to fight such diseases. The WHO's Advisory Committee on Health Research recognizes this fact in its recommendation on Genomics and World Health and stresses the need for concerted efforts by scientists in the developed world, where most of the recent advances in life sciences have occurred, and those in the tropical, mostly less developed countries, where such diseases are endemic. Tropical Diseases: From Molecule to Bedside exemplifies such an effort. It covers a wide range of topics that reflect perspectives of northern and southern hemispheres. Fittingly, it defines tropical diseases in a broader-than-usual manner. For example, the book discusses traditional tropical medicine topics of infectious diseases and nutritional deficiencies. These diseases are common in the tropics, although some are associated more with poverty than with tropical living conditions. It also deals with genetic diseases and genomic issues that are truly associated with living in the tropics, e.g. the thalassemias. The book begins with several papers describing the vast human genetic diversity of Southeast Asia and its relationship to several genetic disorders. These papers illustrate the future direction of genomic activities in relation to disease susceptibility and resistance. The next sections deal with malaria and four specific viral and bacterial diseasesof the tropics: hepatitis B and C, tuberculosis, and leprosy. These are then followed by a section on general bacterial infection. Two papers on nutrition complete the volume.
Proceedings of the second International Eijkman Symposium on Tropical Diseases: From Molecule to Bedside: In the Footsteps of Christiaan Eijkman, held September 2-6, 2001, in Bogor, Indonesia.

The Plasmodium spp. parasite was identified as the causative agent of malaria in 1880, and the mosquito was identified as the vector in 1897. Despite subsequent efforts focused on the epidemiology, cell biology, immunology, molecular biology, and clinical manifestations of malaria and the Plasmodium parasite, there is still no licensed vaccine for the prevention of malaria. Physical barriers (bed nets, window screens) and chemical prevention methods (insecticides and mosquito repellents) intended to interfere with the transmission of the disease are not highly effective, and the profile of resistance of the parasite to chemoprophylactic and chemotherapeutic agents is increasing. The dawn of the new millennium has seen a resurgence of interest in the disease by government and philanthropic organizations, but we are still faced with compl- ities of the parasite, the host, and the vector, and the interactions among them. Malaria Methods and Protocols offers a comprehensive collection of protocols describing conventional and state-of-the-art techniques for the study of malaria, as well as associated theory and potential problems, written by experts in the field. The major themes reflected here include assessing the risk of infection and severity of disease, laboratory models, diagnosis and typing, molecular biology techniques, immunological techniques, cell biology techniques, and field applications.

Tropical medicine is a branch of medicine focusing on disorders usually found in subtropical and tropical areas of the world. Tropical paediatrics is a branch of tropical medicine focusing on children in these areas. The current process of global warming and the widespread issue of international travel are bringing these conditions to many places of the globe. This book highlights selective concepts of tropical paediatrics that are of importance to clinicians caring for children and adolescents.

Human African Trypaniosomiasis (HAT) or sleeping sickness is an old disease to be now considered as reemergent. HAT is endemic in 36 sub-Saharan African countries, in areas where tsetse flies are found. The public health importance of HAT is underestimated, but the disease causes severe social disruption in many rural areas. Along the past fifteen years, numerous studies were made, and now, the mechanisms involved in the disease pathogenesis and in the characteristics of sleep-wake disruption become to be better understood. But, since 50 years, when current drugs were introduced, problems regarding HAT chemotherapy have not been solved. Nevertheless, in-depth studies about trypanosome metabolism have permitted to discover new drug targets. Written by specialists who are very experienced in their respective fields, the contributions provide an indispensable tool for practitioners and scientists.

Cholera is a life-threatening diarrhoeal disease that can spread rapidly and in explosive epidemics from one region to another, affecting large numbers of people. V cholerae, a gram-negative motile bacterium, is the causative agent of this intestinal disease. This book presents topical research from across the globe in the study of cholera; its symptoms, diagnosis and treatment. Some topics discussed, herein, include emergence of new virulence factors of vibrio cholera as potential vaccine candidates; possible targets for quorum quenching of vibrio cholerae; the environmental reservoirs and vector of vibrio cholerae; and current African perspectives of cholera.

The advent of tropical medicine was a direct consequence of European and American imperialism, when military personnel, colonial administrators, businessmen, and settlers encountered a new set of diseases endemic to the tropics. Professor Farley describes how governments and organizations in Britain, the British colonies, the United States, Central and South America, South Africa, China, and the World Health Organization faced one particular tropical disease, bilharzia or schistosomiasis. Bilharzia is caused by a species of blood vessel-inhabiting parasitic worms and today afflicts over 200 million people in seventy-four countries. John Farley demonstrates that British and American imperial policies and attitudes largely determined the nature of tropical medicine. Western medical practitioners defined the type of medical system that was imposed on the indigenous populations; they dictated which diseases were important and worthy of study, which diseases were to be controlled, and which control methods were to be used.

Delivering the facts to your fingertips, the Oxford Handbook of Tropical Medicine provides an accessible and comprehensive, signs-and-symptoms-based source of information on medical problems commonly seen in the tropics. A handy guide which can fit in the coat pocket and be used easily at the bedside, it has been designed to be as practical as possible with illustrations of blood films and stool smears, which are useful for diagnosis, as well as clinical features, diagnosis, and management. Medical conditions are ordered by system except for the five major tropical conditions - malaria, HIV/STIs, tuberculosis, diarrhoeal diseases, and acute respiratory infections - and fevers. In this new edition the sections on malaria, cardiology, chest medicine, gastroenterology, mental health and dermatology have undergone major revision, and there is new material on altitude sickness, heat stroke, avian flu and fuller poisoning. There is a greater emphasis on pediatric medicine and public health throughout, and new illustrations and photographs have been included to aid with diagnosis. Small enough to throw in your rucksack, this unique handbook is the ultimate quick reference guide for all those working in the tropics.

Im Zuge der Globalisierung, bei der Container und Menschen von einem Kontinent zum anderen transportiert werden, landen taglich Erreger oder Krankheitsubertrager in Europa an und koennen sich schnell ausbreiten. Daher ist es notwendig, das Wissen um die UEbertragungswege von Parasiten auf den Menschen stets aktuell zu halten und die Gefahren einer Einschleppung und Ausbreitung rechtzeitig einzudammen. Dieses Buch bietet eine aktuelle UEbersicht uber die wichtigsten einheimischen und tropischen Parasiten des Menschen und ihre potenziellen UEbertrager. Es wendet sich an AErzte, Pharmazeuten, Laborpersonal und Studierende der Humanmedizin und Biologie, aber auch an alle, die sich uber Vorbeuge- und Bekampfungsmassnahmen informieren wollen. Informationen zu den einzelnen Parasiten werden jeweils in 11 Abschnitten komprimiert dargestellt: 1. Namensgebung - 2. Weltweite Verbreitung und epidemiologische Daten - 3. Lebenszyklen und Aussehen - 4. Symptome der Erkrankung - 5. Diagnosemoeglichkeiten - 6. Infektionswege - 7. Vorbeugemassnahmen - 8. Inkubationszeiten - 9. Zeiten bis zur Weiterubertragung - 10. Dauer eines Befalls - 11. Therapiemassnahmen In Tabellen, zahlreichen Schemata und auf 200 farbigen Abbildungen werden die wichtigsten Aspekte eines Parasitenbefalls sowie die aktuellen Bekampfungsmassnahmen dargestellt. Fragen helfen zudem bei der UEberprufung des eigenen Wissens. Die Neuauflage wurde um weitere Erreger erganzt und durch AEnderungen bei den Therapien aktualisiert

Friedrich Frischknecht gibt einen interessanten Einblick in die Lebensweisen von Parasiten. Vom kleinen Erreger der Malaria zum Bandwurm, vom Durchfall zur Verhaltensanderung des Wirts stellt er die faszinierende Welt der Parasiten vor. Dabei verdeutlicht er, warum Parasitismus eine so erfolgreiche Lebensweise darstellt und wie wir es trotzdem schaffen koennten, die schlimmsten Parasiten auszurotten. Der Autor: Prof. Dr. Friedrich Frischknecht hat nach dem Studium der Biochemie an der Freien Universitat Berlin am Europaischen Molekularbiologischen Laboratorium (EMBL) in Heidelberg uber Pockenviren promoviert. Nach einem Forschungsaufenthalt am Institut Pasteur in Paris leitet er seit 2005 eine Forschungsgruppe am Universitatsklinikum in Heidelberg und beschaftigt sich mit den molekularen Grundlagen der Bewegung von Malariaparasiten.

Menschen leben mit und von Tieren und sind in vielfaltiger Weise auf sie angewiesen. Tiere haben nicht nur als Nahrungslieferanten ungeheure Bedeutung, sondern auch als Weggefahrten von Familien oder einsamen Personen. Die Gesundheit der Tiere wird allerdings von Parasiten bedroht, deren Anzahl gerade in Zeiten der Globalisierung mit Transporten von Waren, Pflanzen, Tieren von einem Ende der Welt ans andere standig zunimmt. Viele Parasiten der Haus-, Nutz- und Heimtiere konnen auch den Menschen befallen und als sog. Zoonosen z.T. lebensbedrohliche Erkrankungen hervorrufen.

Daher ist es wichtig, das Wissen zu den Ubertragungswegen solcher Parasiten sowie zu den Vorbeuge- und Bekampfungsmassnahmen standig zu aktualisieren, um Schaden von Mensch und Tier abzuwenden.

Dieses Buch stellt die wichtigsten Parasiten von Hunden, Katzen, Wiederkauern, Pferden, Schweinen, Kaninchen, Nagern, Geflugel, Fischen, Reptilien und Bienen dar, wobei jeder Parasit bzw. jede Parasitose in 11 Abschnitte untergliedert ist: NamensgebungVerbreitung/EpidemiologieMorphologie/LebenszyklusSymptome der ErkrankungDiagnoseInfektionswegProphylaxeInkubationszeitPrapatenzPatenzTherapie

Das Buch bietet komprimierte Informationen zu Parasiten, die die Tiere und den Menschen bedrohen. Es wendet sich daher sowohl an Tierarzte und Studierende der Veterinarmedizin als auch an Laborpersonal und Tierhalter, also alle Personen, die von zoonotischen Parasiten bedroht sind bzw. deren Haustiere darunter leiden. In informativen Texten, auf Tabellen, Schemata und auf uber 500 farbigen Abbildungen werden die wichtigsten Aspekte des Parasitenbefalls dargestellt und aktuelle Hinweise zur Vermeidung und Bekampfung dieser unliebsamen Zeitgenossen gegeben. 100 Fragen helfen bei der Uberprufung des eigenen Wissens.

Ist eine Gefahr erst einmal erkannt, kann sie heute relativ schnell mit geeigneten Massnahmen gebannt werden. Tiere und Menschen sind dann keine gefahrdete Gemeinschaft "

Despite numerous scientific investigations on vector-borne human infections such as malaria, Lyme disease and typhus these diseases continue to threaten human health. Understanding the role of vectors in disease transmission, and the most appropriate control strategies, is therefore essential. This book provides information on the recognition, biology, ecology and medical importance of the arthropods that affect human health. The fifth edition of this popular textbook is completely updated and incorporates the latest strategies for controlling insects, ticks and mites. Numerous illustrations, with new colour photographs of some of the most important vectors, aid recognition. A glossary of entomological and epidemiological terms is included, along with a list of commonly used insecticides and their trade names. Clearly presented in a concise style, this text is aimed at students of medical entomology, tropical medicine, parasitology and pest control. It is also essential reading for physicians, health officials and community health workers.