For more than fifty years, Dr. Cahill has been helping to heal the world, as a leading specialist in tropical medicine and as a driving force in humanitarian assistance and relief efforts around the globe. In this revised and expanded edition, he chronicles extraordinary achievements of compassion and commitment. Bringing together a rich selection of writings, he crafts a fascinating memoir of a life devoted to others. The book includes front-line reports from places under siege Lebanon, Somalia, Sudan, Nicaragua, Gaza, and Ireland; there are also visionary essays from the origins of the AIDS epidemic and landmine crises, and no less passionate concerns of his own experiences of pain and suffering as well as of joy and beauty in the worlds in which he has traveled. As the distinguished neurologist and author Oliver Sacks, M.D., notes in his endorsement, "These essays, by turns elegiac, lyrical, funny, tender, nostalgic, and vehemently impassioned, come together in an ongoing tapestry, a portrait of a dedicated physician who has dared to make a difference."

This practical book covers all aspects of the biology of malaria vectors, with notes on the vectors of dengue. It is the first work in this field to concentrate on mosquitoes, rather than covering all disease vectors. Authored by renowned field entomologist Jacques Derek Charlwood, it disseminates his vast experience working on mosquito biology, ecology and the evaluation of new vector control tools across five continents over the past 40 years. Covering all aspects from classification and systematics, population dynamics, vector control, to surveillance and sampling, epidemics, and a selection of case histories, the book also considers genetics and resistance, Aedes biology, and malaria and dengue models. It is designed to fill the gap between very specialized texts and undergraduate books on general disease vectors, and is ideal as a textbook for postgraduate courses in entomology and mosquito vectors of disease.

This new edition describes the role of heat shock proteins in the life cycle of malaria parasites, particularly in the context of intracellular parasite stages. Thoroughly revised, this work provides a general introduction to the structural and functional features of heat shock proteins with a special focus on their role as molecular chaperones in ensuring protein quality control. The emphasis is on the heat shock protein families from Plasmodium falciparum, and their role in proteostasis and the development of malaria pathology. Moreover, the authors explore the latest prospects of targeting heat shock proteins in antimalarial drug discovery either directly or in combination therapies. Readers will experience a functional analysis of the individual families of heat shock proteins and their cooperation in functional networks, including both the parasite-resident proteome and the exportome released into host cells during intracellular stages. Subcellular and extracellular organelles such as the apicoplast and the Maurer's Clefts associated with Plasmodium species are discussed in detail. The book highlights the role of heat shock proteins in the development and function of these structures. Biochemical expertise and the inclusion of novel therapeutic solutions make this collection a unique reference for experts in heat shock protein research, parasitology and infectious diseases, cell stress, molecular biology and drug discovery. Not least, advances in malaria control will contribute to ending epidemics and ensuring healthy lives in line with the UN Sustainable Development Goals.

Twenty-Six Portland Place is a ground-breaking exploration of the early years of the Royal Society of Tropical Medicine and Hygiene, from its foundation in 1907 to its half-century in 1957. Following its formation at the height of the Empire, it became a forum in which to discuss and develop ideas and current research by physicians and clinical parasitologists into diseases prevalent in warm climates. The book also traces the Society's growth and development through two world wars and the turbulent national, international and medical politics of the period. As a former President of the Society with full access to its archives, Gordon C. Cook is uniquely placed to create this account, which will be of particular interest to historians and clinicians with an interest in tropical medicine, and to fellows of the Society.

An extraordinary array of infectious agents affects humans; from worms, arthopods, and fungi to bacteria, viruses, and prions. In this compendium of the curious and fascinating organisms that cause disease, including Legionnaire's disease, mumps, CJD, and chlamydia, David I. Grove provides a lively, fact-filled account of the nature of each organism, their life cycle, the ingenious ways in which they infect humans, and the human stories behind their discovery.

With the exception of a few tropical medicine schools worldwide, current medical education programs include almost zero discussion of the interface between infectious diseases and entomology. That is why this book was initially published in the first edition almost 17 years ago. The third edition of this valuable infectious disease entomology book updates all existing chapters with the newest scientific developments described in the medical and entomological literature in addition to covering 10 entirely new topics not addressed in previous editions, which include: * arthropod identification controversies * early beginnings of public health and disease control * red-meat allergy * updates on vaccine development for dengue and malaria * discussion of Chikungunya and Zika viruses * American Boutonnneuse Fever * the newest controversies in Lyme disease * recent findings of viruses in ticks * bed bug bite reactions * Morgellons disease (an imaginary infectious disease)

This second edition of the popular advanced student textbook (previously published as "Worms and Disease: A Manual of Medical Helminthology") has been thoroughly updated and revised since it was first published in 1975. It includes contributions and a chapter by Prof. Derek Wakelin, University of Nottingham, UK. * An authoritative handbook covering all human helminth infections with particular emphasis on diagnosis, treatment, clinical manifestations, pathogenesis, epidemiology and control * Practical guidelines are given for estimating the clinical and public significance of helminthiases, vital in areas where the majority of inhabitants are infected with many helminths but only a few are sick.

This comprehensive review provides a systematic, unbiased analysis, critique and summary of the available literature and generates novel clinical decision-making algorithms which can aid clinicians and scientists in practice management and research development. Potential mechanisms for the identified drug interactions are deduced from available preclinical and in vitro data which are interpreted in the context of the in vivo findings. Current limitations and gaps in the literature are summarized, and potential future research directions / experimentations are also suggested. In addition to the main objective to review the available clinical pharmacokinetic and pharmacodynamic drug interactions associated with WHO-recommended antimalarial drugs on the market today (i.e. chloroquine, amodiaquine, sulfadoxine, pyrimethamine, mefloquine, artemisinin, artemether, artesunate, dihydroartemisinin, artemotil, lumefantrine, primaquine, atovaquone, proguanil, piperaquine and quinine), this book also provides succinct chapter summaries on the epidemiology of malaria infection, diagnosis and therapeutics, in vivo pharmacology and chemistry, preclinical pharmacology, in vitro pharmacodynamics, in vitro reaction phenotyping, and in vitro drug-drug interaction data associated with the identified antimalarial drugs.

African trypanosomes are tsetse-transmitted protozoa that inhabit the extracellular compartment of host blood. They cause fatal sleeping sickness in people, and Nagana, a wasting and generally fatal disease, in cattle. While trypanosomes are most common to Africa (about 30% of Africa's cattle graze on the fringe of the tsetse habitat), some species have spread beyond its boarders to Asia, the Middle East and South America. The African Trypanosomes, volume one of World Class Parasites, is written for researchers, students and scholars who enjoy reading research that has a major impact on human health, or agricultural productivity, and against which we have no satisfactory defense. It is intended to supplement more formal texts that cover taxonomy, life cycles, morphology, vector distribution, symptoms and treatment. It integrates vector, pathogen and host biology and celebrates the diversity of approach that comprises modern parasitological research.

It is almost twenty years ago since under Nutricia's auspices the first Nutricia Symposium took place. Professor Jonxis was mainly responsible for the organiza tion of the earlier symposia, whilst Professor Visser organized the fifth Nutricia Symposium in 1978. This book is the commitment to paper of the lectures given during the sixth Nutricia/Cow & Gate Symposium held in Louvain in 1983. Both Professor Eeckels and Professor Ransome-Kuti succeeded in collecting a panel of experts on 'Child Health in the Tropics'. We hope, in fact we are sure, that you will consider the contents of this book a daily stimulation in your medical profession. October 1984 Contents Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . V List of authors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . XI List of participants. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . XIV SESSION I FEEDING, FEEDING PRACTICES AND GROWTH Chairman: Chap-Yung Yeung A. Omololu, The practice of breastfeeding . . . . . . . . . . . . . . . . . . . . . . . . . . 3 M. G. M. Rowland, S. G. l. Goh, S. Tullock, D. T. Dunn and R. l. Hayes, Growth and weaning in urban Gambian infants. . . . . . . . . . . . . . . . . . . . 9 W. Klaver, Some considerations on the formulation of weaning mixes. . 19 R. G. Hendrickse, The influence of mycotoxins on child health in the tropics. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29 V. S. Tanphaichitr, C. Tuchinda, V. Suvatte and S. Tuchinda, Bodily growth in thalassemia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43 L. Sinisterra, Ecological evaluation of human development: the case of the child in the tropics. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51 SESSION II DIARRHOEAL DISEASES Chairman: o. Ransome-Kuti A. M. Molla, S. A. Sarker, A. Molla, M. Kathoon, W. B."

"Networks in Tropical Medicine" explores how European doctors and scientists worked together across borders to establish the new field of tropical medicine in the late nineteenth and early twentieth centuries. The book shows that this transnational collaboration in a context of European colonialism, scientific discovery, and internationalism shaped the character of the new medical specialty. Even in an era of intense competition among European states, practitioners of tropical medicine created a transnational scientific community through which they influenced each other and the health care that was introduced to the tropical world. One of the most important developments in the shaping of tropical medicine as a specialty was the major sleeping sickness epidemic that spread across sub-Saharan Africa at the turn of the century. The book describes how scientists and doctors collaborated across borders to control, contain, and find a treatment for the disease. It demonstrates that these medical specialists' shared notions of "Europeanness," rooted in common beliefs about scientific, technological, and racial superiority, led them to establish a colonial medical practice in Africa that sometimes oppressed the same people it was created to help.

Natural Products in Vector-Borne Disease Management explores the potential application of natural products in vector control and disease management. The chapters discuss the global impact of specific vector-borne diseases, gaps in management, and natural products in specific stages of development - discovery, optimization, validation, and preclinical/clinical development. Toxic effects and mechanisms of action are also discussed. This book also explores how therapeutic plant derivatives can be used to combat the vectors of infection and how natural products can be used to manage and treat vector-borne diseases like malaria, leishmaniasis, dengue, and trypanosomiasis. With the inclusion of case studies on field and clinical applications and the contributions from experts in the field, Natural Products in Vector-Borne Disease Management is an essential resource to researchers, academics, and clinicians in parasitology, virology, microbiology, biotechnology, pharmacology, and pharmacognosy working in the field of vector-borne diseases.

Human African Trypaniosomiasis (HAT) or sleeping sickness is an old disease to be now considered as reemergent. HAT is endemic in 36 sub-Saharan African countries, in areas where tsetse flies are found. The public health importance of HAT is underestimated, but the disease causes severe social disruption in many rural areas. Along the past fifteen years, numerous studies were made, and now, the mechanisms involved in the disease pathogenesis and in the characteristics of sleep-wake disruption become to be better understood. But, since 50 years, when current drugs were introduced, problems regarding HAT chemotherapy have not been solved. Nevertheless, in-depth studies about trypanosome metabolism have permitted to discover new drug targets. Written by specialists who are very experienced in their respective fields, the contributions provide an indispensable tool for practitioners and scientists.

The advent of tropical medicine was a direct consequence of European and American imperialism, when military personnel, colonial administrators, businessmen, and settlers encountered a new set of diseases endemic to the tropics. Professor Farley describes how governments and organizations in Britain, the British colonies, the United States, Central and South America, South Africa, China, and the World Health Organization faced one particular tropical disease, bilharzia or schistosomiasis. Bilharzia is caused by a species of blood vessel-inhabiting parasitic worms and today afflicts over 200 million people in seventy-four countries. John Farley demonstrates that British and American imperial policies and attitudes largely determined the nature of tropical medicine. Western medical practitioners defined the type of medical system that was imposed on the indigenous populations; they dictated which diseases were important and worthy of study, which diseases were to be controlled, and which control methods were to be used.

Delivering the facts to your fingertips, the Oxford Handbook of Tropical Medicine provides an accessible and comprehensive, signs-and-symptoms-based source of information on medical problems commonly seen in the tropics. A handy guide which can fit in the coat pocket and be used easily at the bedside, it has been designed to be as practical as possible with illustrations of blood films and stool smears, which are useful for diagnosis, as well as clinical features, diagnosis, and management. Medical conditions are ordered by system except for the five major tropical conditions - malaria, HIV/STIs, tuberculosis, diarrhoeal diseases, and acute respiratory infections - and fevers. In this new edition the sections on malaria, cardiology, chest medicine, gastroenterology, mental health and dermatology have undergone major revision, and there is new material on altitude sickness, heat stroke, avian flu and fuller poisoning. There is a greater emphasis on pediatric medicine and public health throughout, and new illustrations and photographs have been included to aid with diagnosis. Small enough to throw in your rucksack, this unique handbook is the ultimate quick reference guide for all those working in the tropics.

Im Zuge der Globalisierung, bei der Container und Menschen von einem Kontinent zum anderen transportiert werden, landen taglich Erreger oder Krankheitsubertrager in Europa an und koennen sich schnell ausbreiten. Daher ist es notwendig, das Wissen um die UEbertragungswege von Parasiten auf den Menschen stets aktuell zu halten und die Gefahren einer Einschleppung und Ausbreitung rechtzeitig einzudammen. Dieses Buch bietet eine aktuelle UEbersicht uber die wichtigsten einheimischen und tropischen Parasiten des Menschen und ihre potenziellen UEbertrager. Es wendet sich an AErzte, Pharmazeuten, Laborpersonal und Studierende der Humanmedizin und Biologie, aber auch an alle, die sich uber Vorbeuge- und Bekampfungsmassnahmen informieren wollen. Informationen zu den einzelnen Parasiten werden jeweils in 11 Abschnitten komprimiert dargestellt: 1. Namensgebung - 2. Weltweite Verbreitung und epidemiologische Daten - 3. Lebenszyklen und Aussehen - 4. Symptome der Erkrankung - 5. Diagnosemoeglichkeiten - 6. Infektionswege - 7. Vorbeugemassnahmen - 8. Inkubationszeiten - 9. Zeiten bis zur Weiterubertragung - 10. Dauer eines Befalls - 11. Therapiemassnahmen In Tabellen, zahlreichen Schemata und auf 200 farbigen Abbildungen werden die wichtigsten Aspekte eines Parasitenbefalls sowie die aktuellen Bekampfungsmassnahmen dargestellt. Fragen helfen zudem bei der UEberprufung des eigenen Wissens. Die Neuauflage wurde um weitere Erreger erganzt und durch AEnderungen bei den Therapien aktualisiert

Friedrich Frischknecht gibt einen interessanten Einblick in die Lebensweisen von Parasiten. Vom kleinen Erreger der Malaria zum Bandwurm, vom Durchfall zur Verhaltensanderung des Wirts stellt er die faszinierende Welt der Parasiten vor. Dabei verdeutlicht er, warum Parasitismus eine so erfolgreiche Lebensweise darstellt und wie wir es trotzdem schaffen koennten, die schlimmsten Parasiten auszurotten. Der Autor: Prof. Dr. Friedrich Frischknecht hat nach dem Studium der Biochemie an der Freien Universitat Berlin am Europaischen Molekularbiologischen Laboratorium (EMBL) in Heidelberg uber Pockenviren promoviert. Nach einem Forschungsaufenthalt am Institut Pasteur in Paris leitet er seit 2005 eine Forschungsgruppe am Universitatsklinikum in Heidelberg und beschaftigt sich mit den molekularen Grundlagen der Bewegung von Malariaparasiten.

Menschen leben mit und von Tieren und sind in vielfaltiger Weise auf sie angewiesen. Tiere haben nicht nur als Nahrungslieferanten ungeheure Bedeutung, sondern auch als Weggefahrten von Familien oder einsamen Personen. Die Gesundheit der Tiere wird allerdings von Parasiten bedroht, deren Anzahl gerade in Zeiten der Globalisierung mit Transporten von Waren, Pflanzen, Tieren von einem Ende der Welt ans andere standig zunimmt. Viele Parasiten der Haus-, Nutz- und Heimtiere konnen auch den Menschen befallen und als sog. Zoonosen z.T. lebensbedrohliche Erkrankungen hervorrufen.

Daher ist es wichtig, das Wissen zu den Ubertragungswegen solcher Parasiten sowie zu den Vorbeuge- und Bekampfungsmassnahmen standig zu aktualisieren, um Schaden von Mensch und Tier abzuwenden.

Dieses Buch stellt die wichtigsten Parasiten von Hunden, Katzen, Wiederkauern, Pferden, Schweinen, Kaninchen, Nagern, Geflugel, Fischen, Reptilien und Bienen dar, wobei jeder Parasit bzw. jede Parasitose in 11 Abschnitte untergliedert ist: NamensgebungVerbreitung/EpidemiologieMorphologie/LebenszyklusSymptome der ErkrankungDiagnoseInfektionswegProphylaxeInkubationszeitPrapatenzPatenzTherapie

Das Buch bietet komprimierte Informationen zu Parasiten, die die Tiere und den Menschen bedrohen. Es wendet sich daher sowohl an Tierarzte und Studierende der Veterinarmedizin als auch an Laborpersonal und Tierhalter, also alle Personen, die von zoonotischen Parasiten bedroht sind bzw. deren Haustiere darunter leiden. In informativen Texten, auf Tabellen, Schemata und auf uber 500 farbigen Abbildungen werden die wichtigsten Aspekte des Parasitenbefalls dargestellt und aktuelle Hinweise zur Vermeidung und Bekampfung dieser unliebsamen Zeitgenossen gegeben. 100 Fragen helfen bei der Uberprufung des eigenen Wissens.

Ist eine Gefahr erst einmal erkannt, kann sie heute relativ schnell mit geeigneten Massnahmen gebannt werden. Tiere und Menschen sind dann keine gefahrdete Gemeinschaft "

Despite numerous scientific investigations on vector-borne human infections such as malaria, Lyme disease and typhus these diseases continue to threaten human health. Understanding the role of vectors in disease transmission, and the most appropriate control strategies, is therefore essential. This book provides information on the recognition, biology, ecology and medical importance of the arthropods that affect human health. The fifth edition of this popular textbook is completely updated and incorporates the latest strategies for controlling insects, ticks and mites. Numerous illustrations, with new colour photographs of some of the most important vectors, aid recognition. A glossary of entomological and epidemiological terms is included, along with a list of commonly used insecticides and their trade names. Clearly presented in a concise style, this text is aimed at students of medical entomology, tropical medicine, parasitology and pest control. It is also essential reading for physicians, health officials and community health workers.