Tropical diseases remain a major global concern, not only because they affect a huge part of the world population, but also because of the growing global movement of people associated with employment, tourism, and war. Recent advances in molecular biology, epitomized by the genomic revolution, have brought new promises of powerful scientific approaches to fight such diseases. The WHO's Advisory Committee on Health Research recognizes this fact in its recommendation on Genomics and World Health and stresses the need for concerted efforts by scientists in the developed world, where most of the recent advances in life sciences have occurred, and those in the tropical, mostly less developed countries, where such diseases are endemic. Tropical Diseases: From Molecule to Bedside exemplifies such an effort. It covers a wide range of topics that reflect perspectives of northern and southern hemispheres. Fittingly, it defines tropical diseases in a broader-than-usual manner. For example, the book discusses traditional tropical medicine topics of infectious diseases and nutritional deficiencies. These diseases are common in the tropics, although some are associated more with poverty than with tropical living conditions. It also deals with genetic diseases and genomic issues that are truly associated with living in the tropics, e.g. the thalassemias. The book begins with several papers describing the vast human genetic diversity of Southeast Asia and its relationship to several genetic disorders. These papers illustrate the future direction of genomic activities in relation to disease susceptibility and resistance. The next sections deal with malaria and four specific viral and bacterial diseasesof the tropics: hepatitis B and C, tuberculosis, and leprosy. These are then followed by a section on general bacterial infection. Two papers on nutrition complete the volume.
Proceedings of the second International Eijkman Symposium on Tropical Diseases: From Molecule to Bedside: In the Footsteps of Christiaan Eijkman, held September 2-6, 2001, in Bogor, Indonesia.

The Plasmodium spp. parasite was identified as the causative agent of malaria in 1880, and the mosquito was identified as the vector in 1897. Despite subsequent efforts focused on the epidemiology, cell biology, immunology, molecular biology, and clinical manifestations of malaria and the Plasmodium parasite, there is still no licensed vaccine for the prevention of malaria. Physical barriers (bed nets, window screens) and chemical prevention methods (insecticides and mosquito repellents) intended to interfere with the transmission of the disease are not highly effective, and the profile of resistance of the parasite to chemoprophylactic and chemotherapeutic agents is increasing. The dawn of the new millennium has seen a resurgence of interest in the disease by government and philanthropic organizations, but we are still faced with compl- ities of the parasite, the host, and the vector, and the interactions among them. Malaria Methods and Protocols offers a comprehensive collection of protocols describing conventional and state-of-the-art techniques for the study of malaria, as well as associated theory and potential problems, written by experts in the field. The major themes reflected here include assessing the risk of infection and severity of disease, laboratory models, diagnosis and typing, molecular biology techniques, immunological techniques, cell biology techniques, and field applications.

Human African Trypaniosomiasis (HAT) or sleeping sickness is an old disease to be now considered as reemergent. HAT is endemic in 36 sub-Saharan African countries, in areas where tsetse flies are found. The public health importance of HAT is underestimated, but the disease causes severe social disruption in many rural areas. Along the past fifteen years, numerous studies were made, and now, the mechanisms involved in the disease pathogenesis and in the characteristics of sleep-wake disruption become to be better understood. But, since 50 years, when current drugs were introduced, problems regarding HAT chemotherapy have not been solved. Nevertheless, in-depth studies about trypanosome metabolism have permitted to discover new drug targets. Written by specialists who are very experienced in their respective fields, the contributions provide an indispensable tool for practitioners and scientists.

Over the years, Oxfam has been involved in a wide variety of health-related projects. The Practical Health Guides draw on this experience to put forward ideas on best practice in the provision of health care and services in developing countries The number of refugees and displaced persons has increased greatly in recent years. At least 80 per cent of them are living in tropical or semi-tropical countries where vector-borne diseases, such as malaria, dengue fever and sleeping sickness are common and cause widespread sickness and death in the crowded conditions of refugee camps. This work is intended to help development workers and planners to identify and assess the risks of vector-borne diseases in a camp and to plan and implement cost-effective ways of controlling them. The main vector-borne diseases are described, the importance of identifying the particular disease and its vector and of considering a variety of methods of control is emphasized. The book discusses the need for a community-based approach to vector control, the safe use of insecticides and selection of spraying equipment. Also included are lists of suppliers of insecticides and equipment, sources of advice and recommended texts.

Leishmaniasis is a neglected tropical disease that is known to be transmitted by 90 different species of sandflies which carry 20 Leishmania species that cause human infection particularly in endemic countries. Pathogenesis, Treatment, and Prevention of Leishmaniasis aims to provide information on this vector-borne disease and explore strategies for diagnosis and treatment. The book begins with an overview of leishmaniasis which includes historical and future perspectives of the disease. It also discusses the clinical manifestation of the disease, mechanisms of infection, therapeutic strategies, diagnostics, prevention, and cure of Leishmania parasite. The book goes on to explain new insights and challenges in the development of promising drug targets, biomarkers identification and advance vaccination strategies against leishmaniasis. Chapter contributions brings together diverse areas of expertise making Pathogenesis, Treatment, and Prevention of Leishmaniasis aims to bring together elements of leishmaniasis into one place and be a valuable resource for researchers, health care professionals, and graduate students, working in the field of leishmaniasis.

This well-established clinical textbook covers the spectrum of eye disorders but with a focus on the major preventable and treatable causes of blindness in developing countries. Written specifically to address the information needs of doctors, nurses and medical assistants involved in managing eye patients in tropical and developing nations, the book's practical approach is designed to support those working with limited specialist supervision and equipment. Introductory chapters on anatomy and physiology of the eye and clinical skills are followed by chapters devoted to specific conditions such as xerophthalmia, onchocerciasis, leprosy and HIV. Also included are chapters on paediatric eye disease and visual impairment, and a practical guide to the diagnosis of common eye disorders. Thoroughly revised and updated both in terms of text and illustration, Eye Diseases in Hot Climates Fifth Edition continues to provide relevant, practical advice for health care providers caring for eye patients in nations where blindness and visual impairment remain prevalent. Major rewrite of all chapters, incorporating many new treatments that are increasingly accessible in poorer countries, particularly for retinal disease, trachoma and HIV Thorough update on current epidemiology of worldwide visual impairment and blindness Major overhaul of photographs and illustrations: almost all replaced with new, high quality images

Im Zuge der Globalisierung, bei der Container und Menschen von einem Kontinent zum anderen transportiert werden, landen taglich Erreger oder Krankheitsubertrager in Europa an und koennen sich schnell ausbreiten. Daher ist es notwendig, das Wissen um die UEbertragungswege von Parasiten auf den Menschen stets aktuell zu halten und die Gefahren einer Einschleppung und Ausbreitung rechtzeitig einzudammen. Dieses Buch bietet eine aktuelle UEbersicht uber die wichtigsten einheimischen und tropischen Parasiten des Menschen und ihre potenziellen UEbertrager. Es wendet sich an AErzte, Pharmazeuten, Laborpersonal und Studierende der Humanmedizin und Biologie, aber auch an alle, die sich uber Vorbeuge- und Bekampfungsmassnahmen informieren wollen. Informationen zu den einzelnen Parasiten werden jeweils in 11 Abschnitten komprimiert dargestellt: 1. Namensgebung - 2. Weltweite Verbreitung und epidemiologische Daten - 3. Lebenszyklen und Aussehen - 4. Symptome der Erkrankung - 5. Diagnosemoeglichkeiten - 6. Infektionswege - 7. Vorbeugemassnahmen - 8. Inkubationszeiten - 9. Zeiten bis zur Weiterubertragung - 10. Dauer eines Befalls - 11. Therapiemassnahmen In Tabellen, zahlreichen Schemata und auf 200 farbigen Abbildungen werden die wichtigsten Aspekte eines Parasitenbefalls sowie die aktuellen Bekampfungsmassnahmen dargestellt. Fragen helfen zudem bei der UEberprufung des eigenen Wissens. Die Neuauflage wurde um weitere Erreger erganzt und durch AEnderungen bei den Therapien aktualisiert

For more than fifty years, Dr. Cahill has been helping to heal the world, as a leading specialist in tropical medicine and as a driving force in humanitarian assistance and relief efforts around the globe. In this revised and expanded edition, he chronicles extraordinary achievements of compassion and commitment. Bringing together a rich selection of writings, he crafts a fascinating memoir of a life devoted to others. The book includes front-line reports from places under siege Lebanon, Somalia, Sudan, Nicaragua, Gaza, and Ireland; there are also visionary essays from the origins of the AIDS epidemic and landmine crises, and no less passionate concerns of his own experiences of pain and suffering as well as of joy and beauty in the worlds in which he has traveled. As the distinguished neurologist and author Oliver Sacks, M.D., notes in his endorsement, "These essays, by turns elegiac, lyrical, funny, tender, nostalgic, and vehemently impassioned, come together in an ongoing tapestry, a portrait of a dedicated physician who has dared to make a difference."

One of two spiral-bound manuals which provide a practical training module covering virtually all field techniques needed for the collection and transportation of mosquitos as part of a malaria control programme. The manuals, which can be used to train health workers having no previous experience in entomology or malaria control, are intended to form the backbone of a training programme lasting from three to four weeks. The first manual, which is addressed to learners, provides step-by-step instructions in the field work needed to secure comprehensive information about the mosquito population in a given area. Information is presented in a series of 13 illustrated learning units, moving from the simplest collecting techniques that can be practised in the laboratory to more sophisticated procedures that must be undertaken in the field. Techniques covered include hand collection methods, indoor collection after pyrethrin spraying, direct catches of mosquitos from animal and human bait, and collection of larvae and pupae from breeding sites. To help build competence, learning units deal with the theory underlying each task as well as with the practical skills required. Other units help readers learn how to identify species at all stages of the life-cycle, keep accurate records, and preserve and transport specimens under strictly controlled conditions. The need to gain the cooperation of the community is also thoroughly explained. The second manual, addressed to tutors, offers practical advice on the organization and running of training courses. Like the first manual, the Tutor's Guide is divided into a series of learning units, each with clearly specified learning objectives. Information is provided on the equipment needed for teaching a particular topic or demonstrating a particular technique, and on any support services that may be required. Each unit offers guidance on appropriate teaching methods, with more detailed suggestions supplied in an annex. The manual also reproduces model forms for appraising the performance of individual tasks and provides advice on how to give participants feedback on their progress. The manual concludes with a model questionnaire that can be used to evaluate the effectiveness of the course.

Molecular Advancements in Tropical Diseases Drug Discovery presents in-depth knowledge relating to the detection of infection, epidemiology, drugs against various tropical diseases, new target sites for drug discovery and multidrug resistance issues using bioinformatics tools and approaches. The book's chapters are written by experts in their respective fields so that each disease is covered in a rational manner and with a solid foundation on existing facts and prospective research ideas.

Covering all the major tropical diseases that present a health risk to travelers, this book is an invaluable resource for all practitioners who encounter the post travel patient. With emphasis on clinical signs, diagnosis and treatment, it is the first book to summarize the knowledge of post travel presentations in the otherwise non-immune and non-endemic population and will aid clinicians to evaluate travelers' symptoms.

The book is divided into three parts. The first is an overview of key aspects of travel medicine; the second contains a detailed discussion of multiple viral, bacterial and parasitic infections. The third part provides a syndromic approach to patients with common travel complaints such as diarrhea, fever and respiratory infections. It also includes useful appendices with lists of anti-parasitic drugs and available diagnostic tests.

Friedrich Frischknecht gibt einen interessanten Einblick in die Lebensweisen von Parasiten. Vom kleinen Erreger der Malaria zum Bandwurm, vom Durchfall zur Verhaltensanderung des Wirts stellt er die faszinierende Welt der Parasiten vor. Dabei verdeutlicht er, warum Parasitismus eine so erfolgreiche Lebensweise darstellt und wie wir es trotzdem schaffen koennten, die schlimmsten Parasiten auszurotten. Der Autor: Prof. Dr. Friedrich Frischknecht hat nach dem Studium der Biochemie an der Freien Universitat Berlin am Europaischen Molekularbiologischen Laboratorium (EMBL) in Heidelberg uber Pockenviren promoviert. Nach einem Forschungsaufenthalt am Institut Pasteur in Paris leitet er seit 2005 eine Forschungsgruppe am Universitatsklinikum in Heidelberg und beschaftigt sich mit den molekularen Grundlagen der Bewegung von Malariaparasiten.

Medicinal Chemistry Approaches to Malaria and Other Tropical Disease, Volume 53 in the Annual Reports in Medicinal Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

For more than fifty years, Dr. Cahill has been helping to heal the world, as a leading specialist in tropical medicine and as a driving force in humanitarian assistance and relief efforts around the globe. In this revised and expanded edition, he chronicles extraordinary achievements of compassion and commitment. Bringing together a rich selection of writings, he crafts a fascinating memoir of a life devoted to others. The book includes front-line reports from places under siege Lebanon, Somalia, Sudan, Nicaragua, Gaza, and Ireland; there are also visionary essays from the origins of the AIDS epidemic and landmine crises, and no less passionate concerns of his own experiences of pain and suffering as well as of joy and beauty in the worlds in which he has traveled. As the distinguished neurologist and author Oliver Sacks, M.D., notes in his endorsement, "These essays, by turns elegiac, lyrical, funny, tender, nostalgic, and vehemently impassioned, come together in an ongoing tapestry, a portrait of a dedicated physician who has dared to make a difference."

Tropical Dermatology is reviewed in this issue of Dermatologic Clinics, guest edited by Drs. Scott Norton and Aisha Sethi. Drs. Norton and Sethi have gathered a panel of experts to pen articles on topics including Buruli ulcer, Outbreaks of atypical mycobacterial disease, Streptococcal pyoderma and acute rheumatic fever, Treating MRSA in the tropics, Mosquito-borne hemorrhagic fevers, Dermatologic cases at the National Zoo, Arsenical keratoses, Chagas disease, The AAD's Botswana elective, Gentian violet and similar products used to treat pyodermas, Dermatology in Mali: Leishmaniasis, Albinism in Africa, Female genital mutilation, Use of toxic skin lightening compounds, AIDS and leprosy, and Innate immunity and anti-parasitic vaccine strategies.

Newly organized and featuring new editors and hundreds of new images, Peters' Atlas of Tropical Medicine and Parasitology, Seventh Edition, brings you up to date with today's greatest challenges in tropical medicine. Increased global travel, climate change, human conflict, short-term/large-scale human assemblies, potent therapeutic agents, drug resistance, and vaccine misinformation have contributed to a greatly changed landscape in this complex field. This practical, highly visual guide provides more than 1,300 stunning illustrations, making it an authoritative parasitology resource for accurate diagnosis of complex diseases. Contains hundreds of new images, including more than 50 completely revised life cycles and epidemiological maps. Provides current information on Zika virus, chikungunya virus, Ebola virus, SARS and MERS-CoV caused by enzootic corona virus, tuberculosis, ceftriaxone-resistant gonorrhea, malaria, and much more. Features a completely updated and significantly streamlined text, now organized not only by primary mode of disease transmission, but extended to define disease more strictly according to the route of acquisition - a logical change that reflects the principles applied to control measures for most infections. Presents the knowledge and expertise of new editors Drs. Laura Nabarro, Stephen Morris-Jones, and David A. J. Moore. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

This unique book provides an introduction to the fascinating field of tropical nephrology, covering nephrology, infectious diseases and tropical medicine. These topics are connected since numerous infectious and parasitic diseases affect the kidneys and are endemic in the tropical areas of the globe. Considered neglected tropical diseases by the World Health Organization, they are largely linked to poverty and lack policies to prevent, treat and decrease their prevalence and incidence. The tropics currently encompass nearly 150 countries and account for 40% of the world's population, and it is predicted that by 2050 this figure will rise to 55%. Most of the countries in the tropical regions have been classified by the World Bank as low-middle income countries and have limited access to services, including health care. As such, this highly topical book is of interest to a large number of healthcare professionals and researchers who are in contact with tropical diseases, especially those investigating their complications, such as kidney injury. Divided into 23 chapters, it describes the most prevalent tropical diseases and conditions that affect the kidneys. It also presents the most recent epidemiological data, clinical manifestations, details of kidney involvement, including the pathophysiology of kidney injury, and the current treatment for each disease.

The Emergence of Tropical Medicine in France examines the turbulent history of the ideas, people, and institutions of French colonial and tropical medicine from their early modern origins through World War I. Until the 1890s colonial medicine was in essence naval medicine, taught almost exclusively in a system of provincial medical schools built by the navy in the port cities of Brest, Rochefort-sur-Mer, Toulon, and Bordeaux. Michael A. Osborne draws out this separate species of French medicine by examining the histories of these schools and other institutions in the regional and municipal contexts of port life. Each site was imbued with its own distinct sensibilities regarding diet, hygiene, ethnicity, and race, all of which shaped medical knowledge and practice in complex and heretofore unrecognized ways. Osborne argues that physicians formulated localized concepts of diseases according to specific climatic and meteorological conditions, and assessed, diagnosed, and treated patients according to their ethnic and cultural origins. He also demonstrates that regions, more so than a coherent nation, built the empire and specific medical concepts and practices. Thus, by considering tropical medicine's distinctive history, Osborne brings to light a more comprehensive and nuanced view of French medicine, medical geography, and race theory, all the while acknowledging the navy's crucial role in combating illness and investigating the racial dimensions of health.

Menschen leben mit und von Tieren und sind in vielfaltiger Weise auf sie angewiesen. Tiere haben nicht nur als Nahrungslieferanten ungeheure Bedeutung, sondern auch als Weggefahrten von Familien oder einsamen Personen. Die Gesundheit der Tiere wird allerdings von Parasiten bedroht, deren Anzahl gerade in Zeiten der Globalisierung mit Transporten von Waren, Pflanzen, Tieren von einem Ende der Welt ans andere standig zunimmt. Viele Parasiten der Haus-, Nutz- und Heimtiere konnen auch den Menschen befallen und als sog. Zoonosen z.T. lebensbedrohliche Erkrankungen hervorrufen.

Daher ist es wichtig, das Wissen zu den Ubertragungswegen solcher Parasiten sowie zu den Vorbeuge- und Bekampfungsmassnahmen standig zu aktualisieren, um Schaden von Mensch und Tier abzuwenden.

Dieses Buch stellt die wichtigsten Parasiten von Hunden, Katzen, Wiederkauern, Pferden, Schweinen, Kaninchen, Nagern, Geflugel, Fischen, Reptilien und Bienen dar, wobei jeder Parasit bzw. jede Parasitose in 11 Abschnitte untergliedert ist: NamensgebungVerbreitung/EpidemiologieMorphologie/LebenszyklusSymptome der ErkrankungDiagnoseInfektionswegProphylaxeInkubationszeitPrapatenzPatenzTherapie

Das Buch bietet komprimierte Informationen zu Parasiten, die die Tiere und den Menschen bedrohen. Es wendet sich daher sowohl an Tierarzte und Studierende der Veterinarmedizin als auch an Laborpersonal und Tierhalter, also alle Personen, die von zoonotischen Parasiten bedroht sind bzw. deren Haustiere darunter leiden. In informativen Texten, auf Tabellen, Schemata und auf uber 500 farbigen Abbildungen werden die wichtigsten Aspekte des Parasitenbefalls dargestellt und aktuelle Hinweise zur Vermeidung und Bekampfung dieser unliebsamen Zeitgenossen gegeben. 100 Fragen helfen bei der Uberprufung des eigenen Wissens.

Ist eine Gefahr erst einmal erkannt, kann sie heute relativ schnell mit geeigneten Massnahmen gebannt werden. Tiere und Menschen sind dann keine gefahrdete Gemeinschaft "

Advances in Parasitology is a series of up-to-date reviews of all areas of interest in contemporary parasitology. It includes medical studies on parasites of major influence, such as typanosomiasis and scabies, and more traditional areas, such as zoology, taxonomy, and life history, which shape current thinking and applications.

"Networks in Tropical Medicine" explores how European doctors and scientists worked together across borders to establish the new field of tropical medicine in the late nineteenth and early twentieth centuries. The book shows that this transnational collaboration in a context of European colonialism, scientific discovery, and internationalism shaped the character of the new medical specialty. Even in an era of intense competition among European states, practitioners of tropical medicine created a transnational scientific community through which they influenced each other and the health care that was introduced to the tropical world. One of the most important developments in the shaping of tropical medicine as a specialty was the major sleeping sickness epidemic that spread across sub-Saharan Africa at the turn of the century. The book describes how scientists and doctors collaborated across borders to control, contain, and find a treatment for the disease. It demonstrates that these medical specialists' shared notions of "Europeanness," rooted in common beliefs about scientific, technological, and racial superiority, led them to establish a colonial medical practice in Africa that sometimes oppressed the same people it was created to help.

In the 1940s and 1950s, Albert Schweitzer was one of the best-known figures on the world stage. Courted by monarchs, world statesmen, and distinguished figures from the literary, musical, and scientific fields, Schweitzer was awarded the Nobel Peace Prize in 1952, cementing his place as one of the great intellectual leaders of his time. Schweitzer is less well known now but nonetheless a man of perennial fascination, and this volume seeks to bring his achievements across a variety of areas—philosophy, theology, and medicine—into sharper focus. To that end, international scholars from diverse disciplines offer a wideranging examination of Schweitzer’s life and thought over the course of forty years. Albert Schweitzer in Thought and Action gives readers a fuller, richer, and more nuanced picture of this controversial but monumental figure of twentieth-century life—and, in some measure, of that complex century itself.

Malaria sickens hundreds of millions of people--and kills one to three million--each year. Despite massive efforts to eradicate the disease, it remains a major public health problem in poorer tropical regions. But malaria has not always been concentrated in tropical areas. How did other regions control malaria and why does the disease still flourish in some parts of the globe?

From Russia to Bengal to Palm Beach, Randall Packard's far-ranging narrative traces the natural and social forces that help malaria spread and make it deadly. He finds that war, land development, crumbling health systems, and globalization--coupled with climate change and changes in the distribution and flow of water--create conditions in which malaria's carrier mosquitoes thrive. The combination of these forces, Packard contends, makes the tropical regions today a perfect home for the disease.

Authoritative, fascinating, and eye-opening, this short history of malaria concludes with policy recommendations for improving control strategies and saving lives.