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Progress in Human African Trypanosomiasis, Sleeping Sickness (Paperback, 1999 ed.)
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Progress in Human African Trypanosomiasis, Sleeping Sickness (Paperback, 1999 ed.)
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Human African Trypaniosomiasis (HAT) or sleeping sickness is an old
disease to be now considered as reemergent. HAT is endemic in 36
sub-Saharan African countries, in areas where tsetse flies are
found. The public health importance of HAT is underestimated, but
the disease causes severe social disruption in many rural areas.
Along the past fifteen years, numerous studies were made, and now,
the mechanisms involved in the disease pathogenesis and in the
characteristics of sleep-wake disruption become to be better
understood. But, since 50 years, when current drugs were
introduced, problems regarding HAT chemotherapy have not been
solved. Nevertheless, in-depth studies about trypanosome metabolism
have permitted to discover new drug targets. Written by specialists
who are very experienced in their respective fields, the
contributions provide an indispensable tool for practitioners and
scientists.
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