Kisspeptin has been shown to be both necessary and sufficient for activation of the reproductive axis, during puberty and later in adulthood. This makes kisspeptin a fundamental component of the reproductive axis. Kisspeptin has been deemed the single most potent stimulator of GnRH neurons yet known. The importance of kisspeptin has been documented in humans as well as non-human animal models, ranging from monkeys, sheep, and rodents to numerous fish species, thus signifying a highly conserved nature of its reproductive function. Importantly, kisspeptin neurons seem to mediate many of the regulatory effects of other signals, whether they are metabolic, circadian, hormonal, or stress. This places kisspeptin neurons in a unique position to be key nodal points and conduits for conveying numerous endogenous and exogenous signals to the reproductive axis.

This book presents a selection of new insights in understanding and mitigating impacts on wildlife and their habitats. Topics such as, species behaviour and responses; collision risk and fatality estimation; landscape features and gradients, are considered. Other chapters in the book cover the results of current research on mitigation; compensation; effectiveness of measures; monitoring and long-term effects; planning and siting. Examples are given of current research on shutdown on demand and curtailment algorithms. By identifying what we have learned so far, and which predominate uncertainties and gaps remain for future research, this book contributes to the most up to date knowledge on research and management options. This book includes presentations from the Conference on Wind Energy and Wildlife impacts (CWW15), March 2015, hosted by the Berlin Institute of Technology, which offered a platform to national and international participants to showcase the current state of knowledge in wind energy's wildlife implications.

The study of animal communication has led to significant progress in our general understanding of motor and sensory systems, evolution, and speciation. However, one often neglected aspect is that signal exchange in every modality is constrained by noise, be it in the transmission channel or in the nervous system. This book analyses whether and how animals can cope with such constraints, and explores the implications that noise has for our understanding of animal communication. It is written by leading biologists working on different taxa including insects, fish, amphibians, lizards, birds, and mammals. In addition to this broad taxonomic approach, the chapters also cover a wide array of research disciplines: from the mechanisms of signal production and perception, to the behavioural ecology of signalling, the evolution of animal communication, and conservation issues. This volume promotes the integration of the knowledge gained by the diverse approaches to the study of animal communication and, at the same time, highlights particularly interesting fields of current and future research.

"

This book reviews some of the most important scientific and philosophical theories concerning the nature of mind and consciousness. Current theories on the mind-body problem and the neural correlates of consciousness are presented through a series of biographical sketches of the most influential thinkers across the fields of philosophy of mind, psychology and neuroscience. The book is divided into two parts: the first is dedicated to philosophers of mind and the second, to neuroscientists/experimental psychologists. Each part comprises twenty short chapters, with each chapter being dedicated to one author. A brief introduction is given on his or her life and most important works and influences. The most influential theory/ies developed by each author are then carefully explained and examined with the aim of scrutinizing the strengths and weaknesses of the different approaches to the nature of consciousness.

This authoritative volume explores advances in the techniques used to measure percutaneous penetration of drugs and chemicals to assess bioavailability and bioequivalence and discusses how they have been used in clinical and scientific investigations. Seven comprehensive sections examine topics including in vitro drug release, topical drugs products, clinical studies, and guidelines and workshop reports, among others. The book also describes how targeted transdermal drug delivery and more sophisticated mathematical modelling can aid in understanding the bioavailability of transdermal drugs. The first edition of this book was an important reference guide for researchers working to define the effectiveness and safety of drugs and chemicals that penetrated the skin. This second edition contains cutting-edge advances in the field and is a key resource to those seeking to define the bioavailability and bioequivalence of percutaneously active compounds to improve scientific and clinical investigation and regulation.

Animal models and tests have become increasingly important for biomedical research, enabling a better understanding of pathogenic pathways involved in various human disorders. Over the last decades, zebrafish (Danio rerio) have become a very popular model organism in biomedical research. Recently, this fish has entered the waters of neuroscience and biological psychiatry, quickly becoming an indispensable model species in this field. With a high genetic homology to humans (~75% based on coding regions), it is not surprising that humans and fish are very similar physiologically (and behaviorally). Therefore, it should not come as a surprise that zebrafish can be an excellent model of human neuropsychiatric disorders. While some classical psychiatrists may not too easily be persuaded by this generalization, the current book "The rights and wrongs of zebrafish: principles of behavioral phenotyping and CNS disease modeling" explains, in a domain-by-domain manner, how exactly zebrafish models can be used to target a wide range of human brain disorders and aberrant phenotypes. The contributors to this book are leading international scholars whose work spearheads innovative zebrafish neuroscience research around the world. Written by top experts in the field, this book makes for a useful, balanced and up-to-date reading that outlines the use of zebrafish to study the pathological mechanisms underlying neuropsychiatric disorders.

Neither pest management nor resistance management can occur with only an understanding of pest biology. For years, entomologists have understood, with their use of economic thresholds, that at least a minimal use of economics was necessary for proper integrated pest management. IRM is even more complicated and dependent on understanding and using socioeconomic factors. The new edition of "Insect Resistance Management" addresses these issues and much more.

Many new ideas, facts and case studies have been developed since the previous edition of "Insect Resistance Management" published. With a new chapter focusing on Resistance Mechanisms Related to Plant-incorporated Toxins and heavily expanded revisions of several existing chapters, this new volume will be an invaluable resource for IRM researchers, practitioners, professors and advanced students. Authors in this edition include professors at major universities, leaders in the chemical and seed industry, evolutionary biologists and active IRM practitioners. This revision also contains more information about IRM outside North America, and a modeling chapter contains a large new section on uncertainty analysis, a subject recently emphasized by the U.S. Environmental Protection Agency. The final chapter contains a section on insecticidal seed treatments.

No other book has the breadth of coverage of "Insect Resistance Management, 2e." It not only covers molecular to economic issues, but also transgenic crops, seed treatments and other pest management tactics such as crop rotation. Major themes continuing from the first edition include the importance of using IRM in the integrated pestmanagement paradigm, the need to study and account for pest behavior, and the influence of human behavior and decision making in IRM.
Provides insights from the history of insect resistance management (IRM) to the latest scienceIncludes contributions from experts on ecological aspects of IRM, molecular and population genetics, economics, and IRM social issuesOffers biochemistry and molecular genetics of insecticides presented with an emphasis on recent researchEncourages scientists and stakeholders to implement and coordinate strategies based on local social conditions"

This book examines how biotechnology can improve livestock breeding and farming, and thereby also animal products. In the first chapters the reader will discover which techniques and approaches are currently used to improve animal breeding, animal health and the value of animal products. Particular attention is given to reproduction techniques, animal nutrition and livestock vaccines that not only enhance animal health but also have a significant effect on human health by ensuring safe food procurement and preventing zoonotic diseases. In addition, modern biotechnology can increase not only productivity but also the consistency and quality of animal food, fiber and medical products. In the second part of the book, issues such as how animal biotechnology could affect the environment and the important topic of animal waste management are explored. In the concluding chapter, the authors discuss future challenges related to animal biotechnology. This work will appeal to a wide readership, from scientists and professionals working in animal production, to those in farm animal management and veterinary science.

First published in 1943, "Vitamins and Hormones" is the longest-running serial published by Academic Press.

The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed.

This volume focuses on endocrine disrupters.

Key features: Expertise of the contributorsCoverage of a vast array of subjectsIn depth current information at the molecular to the clinical levelsThree-dimensional structures in colorElaborate signaling pathways "

Mammals range in body size from the gigantic blue whale to the tiny Etruscan shrew. Elephants and man may live for nearly one hundred years, while most shrews die before they are three months old. During the past decade, mammalogists and evolutionary biologists have begun to unravel the numerous factors that shape the enormous diversity of mammal life histories. In this volume, leading scientists provide a variety of perspectives on the newest theories in this active field of study. The principle uniting all studies of life history evolution is adaptation by natural selection. The first chapters in the book discuss this topic, offering evolutionary interpretations of geographic variation in mammal life histories, explaining how natural selection operates in fluctuating environments, introducing evolutionary predictions of demographic mathematics, and integrating life histories with behavioral ecology. The next chapters offer functional interpretations of the importance of body size in the life history. Next, several essays explain how developments in quantitative genetics have enabled us to distinguish between genetic and environmental components of variation within and between species. With this as a basis, the chapters that follow draw from principles of natural selection, allometry, and genetics to interpret differences among species of mammals. The book concludes with speculations on various areas where research seems most urgent for the development of a comprehensive understanding of mammal life history evolution. According to the authors, the field is rich with questions, and opportunities abound for both theoretical and empirical research.

Amphibian Conservation is the fourth in the series of Synopses of Conservation Evidence, linked to the online resource www.ConservationEvidence.com. This synopsis is part of the Conservation Evidence project and provides a useful resource for conservationists. It forms part of a series designed to promote a more evidence-based approach to biodiversity conservation. Others in the series include bee, bird, farmland and bat conservation and many others are in preparation. Approximately 32% of the 7,164+ amphibian species are currently threatened with extinction and at least 43% of species are declining. Despite this, until recently amphibians and their conservation had received little attention. Although work is now being carried out to conserve many species, often it is not adequately documented. This book brings together and summarises the available scientific evidence and experience relevant to the practical conservation of amphibians. The authors consulted an international group of amphibian experts and conservationists to produce a thorough summary of what is known, or not known, about the effectiveness of amphibian conservation actions across the world. "The book is packed with literature summaries and citations; a veritable information goldmine for graduate students and researchers. It also admirably provides decision makers with a well-researched resource of proven interventions that can be employed to stem/reverse the decline of amphibian populations." -John G Palis, Bulletin of the Chicago Herpetological Society

Amphibian Conservation is the fourth in the series of Synopses of Conservation Evidence, linked to the online resource www.ConservationEvidence.com. This synopsis is part of the Conservation Evidence project and provides a useful resource for conservationists. It forms part of a series designed to promote a more evidence-based approach to biodiversity conservation. Others in the series include bee, bird, farmland and bat conservation and many others are in preparation. Approximately 32% of the 7,164+ amphibian species are currently threatened with extinction and at least 43% of species are declining. Despite this, until recently amphibians and their conservation had received little attention. Although work is now being carried out to conserve many species, often it is not adequately documented. This book brings together and summarises the available scientific evidence and experience relevant to the practical conservation of amphibians. The authors consulted an international group of amphibian experts and conservationists to produce a thorough summary of what is known, or not known, about the effectiveness of amphibian conservation actions across the world. "The book is packed with literature summaries and citations; a veritable information goldmine for graduate students and researchers. It also admirably provides decision makers with a well-researched resource of proven interventions that can be employed to stem/reverse the decline of amphibian populations." -John G Palis, Bulletin of the Chicago Herpetological Society

In Mouse Molecular Embryology: Methods and Protocols, expert researchers in the field detail many of the protocols used to study mouse embryology. These include protocols and techniques that are "close to the embryo": such as, manipulating embryonic gene expression, culturing explanted embryonic tissue and harvesting embryonic RNA. With additional chapters on fluorescence imaging, lineage tracing, and genetic ablation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Mouse Molecular Embryology: Methods and Protocols seeks to aid scientist in the further study of mouse embryo and its relation to other aspects of biological research.

This book brings together scientific evidence and experience relevant to the practical conservation of bats. The authors worked with an international group of bat experts and conservationists to develop a global list of interventions that could benefit bats. For each intervention, the book summarises studies captured by the Conservation Evidence project, where that intervention has been tested and its effects on bats quantified. The result is a thorough guide to what is known, or not known, about the effectiveness of bat conservation actions throughout the world. Bat Conservation is the fifth in a series of Synopses that will cover different species groups and habitats, gradually building into a comprehensive summary of evidence on the effects of conservation interventions for all biodiversity throughout the world. By making evidence accessible in this way, we hope to enable a change in the practice of conservation, so it can become more evidence-based. We also aim to highlight where there are gaps in knowledge. Evidence from all around the world is included. If there appears to be a bias towards evidence from northern European or North American temperate environments, this reflects a current bias in the published research that is available to us. Conservation interventions are grouped primarily according to the relevant direct threats, as defined in the International Union for the Conservation of Nature (IUCN)'s Unified Classification of Direct Threats (www.iucnredlist.org/technical-documents/classification-schemes).

Advances in the Study of Behavior was initiated over 40 years ago to serve the increasing number of scientists engaged in the study of animal behavior. That number is still expanding. This volume makes another important "contribution to the development of the field" by presenting theoretical ideas and research to those studying animal behavior and to their colleagues in neighboring fields.
Initiated over 40 years ago to serve the increasing number of scientists engaged in the study of animal behaviorMakes another important contribution to the development of the field Presents theoretical ideas and research to those studying animal behavior and to their colleagues in neighboring fields

Advances in the Study of Behavior was initiated over 40 years ago to serve the increasing number of scientists engaged in the study of animal behavior. That number is still expanding. This volume makes another important "contribution to the development of the field" by presenting theoretical ideas and research to those studying animal behavior and to their colleagues in neighboring fields.
Initiated over 40 years ago to serve the increasing number of scientists engaged in the study of animal behavior Makes another important contribution to the development of the field Presents theoretical ideas and research to those studying animal behavior and to their colleagues in neighboring fields

'What is emotion?' pondered the young Charles Darwin in his notebooks. How were the emotions to be placed in an evolutionary framework? And what light might they shed on human-animal continuities? These were among the questions Darwin explored in his research, assisted both by an acute sense of observation and an extraordinary capacity for fellow feeling, not only with humans but with all animal life. "After Darwin: Animals, Emotions, and the Mind "explores questions of mind, emotion and the moral sense which Darwin opened up through his research on the physical expression of emotions and the human-animal relation. It also examines the extent to which Darwin's ideas were taken up by Victorian writers and popular culture, from George Eliot to the "Daily News." Bringing together scholars from biology, literature, history, psychology, psychiatry and paediatrics, the volume provides an invaluable reassessment of Darwin's contribution to a new understanding of the moral sense and emotional life, and considers the urgent scientific and ethical implications of his ideas today.

The classic literature on predation dealt almost exclusively with solitary predators and their prey. Going back to Lotka-Volterra and optimal foraging theory, the theory about predation, including predator-prey population dynamics, was developed for solitary species. Various consequences of sociality for predators have been considered only recently. Similarly, while it was long recognized that prey species can benefit from living in groups, research on the adaptive value of sociality for prey species mostly emerged in the 1970s. The main theme of this book is the various ways that predators and prey may benefit from living in groups. The first part focusses on predators and explores how group membership influences predation success rate, from searching to subduing prey. The second part focusses on how prey in groups can detect and escape predators. The final section explores group size and composition and how individuals respond over evolutionary times to the challenges posed by chasing or being chased by animals in groups. This book will help the reader understand current issues in social predation theory and provide a synthesis of the literature across a broad range of animal taxa.
Includes the whole taxonomical range rather than limiting it to a select fewFeatures in-depth analysis that allows a better understanding of many subtleties surrounding the issues related to social predationPresents both models and empirical results while covering the extensive predator and prey literatureContains extensive illustrations and separate boxes that cover more technical features, i.e., to present models and review results

N.N. Ladygina-Kohts earned her degree in comparative psychology at Moscow University in 1917, then became the first curator of the Darwin Museum in Moscow. Her pioneering work with the chimpanzee, Joni, was reported throughout the continent during her lifetime, earning her a series of honors in the Soviet Union. Unfortunately, Infant Chimpanzee and Human Child, her diary comparing Joni's development with that of her son, Rudy, had never been translated completely. This volume presents the first, complete English translation with 120 photographs, an introduction by Allen and Beatrix Gardner of the Center for Advanced Study at the University of Nevada and an Afterword by Lisa A. Parr, Signe Preuschoft, and Frans B. M. de Waal of the Living Links Center.