Mouse Models of Cancer - Methods and Protocols (Hardcover, 2015 ed.)

This volume is essential for geneticists, molecular biologists, biochemists, and medical doctors interested in the use of mouse models in cancer research. Recent genome studies, together with refined genetic engineering techniques, have greatly increased the value of using mice for research on cancer and other human disorders. The chapters of this book will support scientists in choosing the most suitable mouse models for their research questions. The book provides detailed methodological information for genetic or chemical induction of different types of cancer, histomorphometric cancer analysis, and in vivo imaging, as well as protocols to investigate oncogene addiction, immune surveillance, and hallmarks of cancer such as angiogenesis or metastasis. Four review-like articles provide background information on mouse technologies and histopathologic differences between mouse and human cancers. The mouse models described in individual chapters will fuel the understanding of cancer initiation, immune system roles, tumor angiogenesis, invasion, metastasis, and the relevance of molecular diversity observed among human cancers. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and resourceful, Mouse Models of Cancers: Methods and Protocols, is a valuable laboratory resource for all researchers, from the graduate level upwards, who study cancer and new possibilities for its treatment.

General

Imprint:	HumanaPress
Country of origin:	United States
Series:	Methods in Molecular Biology, 1267
Release date:	February 2015
First published:	2015
Editors:	Robert Eferl • Emilio Casanova
Dimensions:	254 x 178 x 27mm (L x W x T)
Format:	Hardcover
Pages:	463
Edition:	2015 ed.
ISBN-13:	978-1-4939-2296-3
Categories:	Books > Science & Mathematics > Biology, life sciences > Zoology & animal sciences > Animal pathology & diseases Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General
LSN:	1-4939-2296-3
Barcode:	9781493922963

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