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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Immunological Aspects of the Liver and Gastrointestinal Tract (Paperback, Softcover reprint of the original 1st ed. 1976)
Loot Price: R1,558
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Immunological Aspects of the Liver and Gastrointestinal Tract (Paperback, Softcover reprint of the original 1st ed. 1976)
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We have been privileged to start our academic careers at the begin
ning of the decade in which the immunological roles and
hypersensitivity diseases of the gastrointestinal tract and liver
have been defined. In the early 1960s IgA was reported to be the
main secretory immunoglobulin, immunoblasts were shown to home to
the intestinal mucosa and certain serum autoantibodies were
described in patients with chronic liver disease. Shortly
thereafter IgE and Australia antigen were discovered. Parallel
advances in clinical investigation, in particular closed biopsy
techniques, facilitated correlation of morphological changes with
im munological mechanisms in disease of the gastrointestinal tract
and liver. Only 10 years later, the concepts of immunity and
hypersensitivity are regularly applied to the pathogenesis,
diagnosis, treatment and prog nosis of many chronic diseases in
these organs. In designing this book we have attempted to integrate
theorectical and clinical immunology as they pertain in 1975; our
ultimate aim is aptly described by Brachet as quoted by Professor
Paronetto (page 319). We would like to think that this review
provides a basis for the next major advances in the fields of
gastrointestinal and hepatic immunology. As we see it, the
outstanding problem in both sites is how to produce protective
immunity without hypersensitivity."
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