Prokaryotic and Eukaryotic Heat Shock Proteins in Infectious
Disease provides the most current review of the literature relating
to the role and influence of heat shock (stress) proteins on the
establishment, progression and resolution of infectious disease.
Written by leaders in the field of heat shock proteins (HSP) and
their biological and immunological properties, the contributors
provide a fascinating insight into the complex relationship
between, and the involvement of prokaryotic and eukaryotic HSP in
disease states. It has been known for some considerable time that
heat shock proteins from prokaryotic organisms are immunodominant
molecules that are intimately involved in the induction of
potential protective inflammatory responses, and this aspect of HSP
biology is updated herein. In addition to regulating heat shock
protein gene expression, the transcription factor HSF1 also appears
to play an important role in regulating immune responses to
infection. Heat shock proteins are now known to influence
infectious disease processes in a number of diverse ways: they are
involved in the propagation of prions, the replication and
morphogenesis of viruses, and the resistance of parasites to
chemotherapy. These proteins also appear to be important mediators
of bacteria-host interactions and inflammation, the latter via
interactions with cell surface molecules and structures such as
Toll-like receptors and lipid rafts. Heat shock proteins can be
expressed on the surface of infected cells, and this is likely to
provide a target for the innate immune response. Elevated levels of
circulating HSP are present in infectious diseases and these
proteins might therefore regulate inflammatory responses to
pathogenic challenge on a systemic basis. Heat shock proteins are
also implicated in the impact of genital tract infections on the
reproductive outcome, as well as in the local and systemic
consequences of periodontal disease. Fever-range temperatures can
induce the expression of heat shock proteins, and the final chapter
in the book examines the influence of fever-range hyperthermia on a
variety of cells and the organization of plasma membranes. This
book is an essential read for graduates and postgraduates in
Biology, pro- and eukaryotic Biochemistry, Immunology,
Microbiology, Inflammatory and Infectious Disease, and
Pathology.
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