Toxin-Induced Models of Neurological Disorders (Hardcover, 1994 ed.)

Tbis volume discusses and evaluates the use of neurotoxins to produce animal models of human neurodegenerative diseases. Tbe models presented use neuro toxins to induce some or most of the pathophysiological changes (including behavioral) that characterize the most studied motor neuron disorders and cogni tive disorders (dementia) in humans. Within the biomedical research community, there is little doubt about the utility of such models. But with increasing frequen cy, individuals concemed with animal rights question the validity of such models and argue that they actually produce no useful information for understanding or developing treatments for human disorders. Each of the chapters will address this issue, considering the utility, validity, generalizability, and limitations of the models presented. Chapter 1 begins with a brief review of the ethics of animal use in neuro biological research, inc1uding a discussion of the criteria that may be used to evaluate animal models of human disease and extrapolate from the model to appropriate questions regarding humans. The limitations of such extrapolation are also discussed, with special consideration of issues specific to the use of neurotoxins. Chapter 2 extends this theme with further consideration of issues and strategies involved in developing neurotoxin-induced models of neuro degenerative disorders and assessing risk factors associated with neurotoxin ex posure. It then narrows to evaluate the use of a model systems approach to explore neurotoxin-induced leaming and memory deficits in animals as related to humans with dementia."

General

Imprint:	Kluwer Academic / Plenum Publishers
Country of origin:	United States
Release date:	2001
First published:	1994
Editors:	A. J. Nonneman • M.L. Woodruff
Dimensions:	235 x 155 x 25mm (L x W x T)
Format:	Hardcover
Pages:	344
Edition:	1994 ed.
ISBN-13:	978-0-306-44614-6
Categories:	Books > Medicine > Clinical & internal medicine > Neurology & clinical neurophysiology Books > Medicine > Other branches of medicine > Pharmacology > General Promotions
LSN:	0-306-44614-6
Barcode:	9780306446146

Is the information for this product incomplete, wrong or inappropriate? Let us know about it.

Does this product have an incorrect or missing image? Send us a new image.

Is this product missing categories? Add more categories.

Review This Product

No reviews yet - be the first to create one!