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Books > Science & Mathematics > Biology, life sciences > Biochemistry
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The Proprotein Convertases - Discovery, Characteristics, and Link to Tumor Progression and Metastasis (Paperback)
Loot Price: R1,018
Discovery Miles 10 180
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The Proprotein Convertases - Discovery, Characteristics, and Link to Tumor Progression and Metastasis (Paperback)
Series: Colloquium Series on Protein Activation and Cancer
Expected to ship within 18 - 22 working days
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Proprotein convertases (PCs) are a family of proteases including
PC1, PC2, Furin, PC4, PACE4, PC5, and PC7. These enzymes are
involved in the maturation of many precursor proteins involved in
the process of tumorigenesis and metastasis. Since their discovery,
PCs were suggested as potential targets for anti-cancer therapy,
and their activity was found to directly affect tumor cell
proliferation, migration invasion, and the malignant phenotypes of
tumor cells. Here, we discuss a number of previous and recent
findings on the PCs features, their implication in the regulation
of multiple cellular functions that impact on the
invasive/metastatic potential of cancer cells, and their clinical
relevance in cancer patients. Among the substrates of the
proprotein convertases, various growth factors, their receptors,
adhesion molecules, and proteases were identified. The PCs are
inhibited by endogenous and exogenous inhibitors. To date, only
pro7B2, a specific chaperone of PC2, and the granine-like precursor
of neuroendocrine protein proSAAS, a selective ligand of PC1, have
been identified as endogenous inhibitors of the PCs found in the
regulated pathway. However, only PCs prosegments, several
bioengineered inhibitors, peptides, and non-peptide compounds were
found to inhibit the activity of the PCs found in the secretory
pathway.
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