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Plasmid Mediated Antibiotic Resistance in Gram-Negative Bacteria (Paperback)
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Plasmid Mediated Antibiotic Resistance in Gram-Negative Bacteria (Paperback)
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The enteric pathogens isolated from diarrhoeal patients admitted to
different hospitals of Azad Jammu & Kashmir were analyzed for
antibiotic resistance and correlated with genetic elements in the
bacteria.Salmonella spp. was the most frequently detected (35.8 %)
enteropathogen followed by Escherichia coli (34.3 %), Shigella
spp.(25.8 %) and Campylobacter spp. (4.1 %). The isolates of
Shigella spp. showed highest resistance against penicillin, E. coli
and Campylobacter spp. against carbenicillin, and Salmonella spp.
were highly resistant to ampicillin.The most common pattern of
antibiotic resistance was penicillin, carbenicillin and ampicillin
in Shigella spp.; carbenicillin, ampicillin and ceftizoxime in E.
coli;ampicillin, carbenicillin and streptomycin in Salmonella spp.;
and carbenicillin, ampicillin and co-trimoxazole in Campylobacter
spp. The drug resistant bacteria were analyzed for the presence of
plasmid DNA. Since the plasmid DNA is implicated for drug resistant
gene(s), curing bacteria of plasmid abolished drug resistance,
whereas transformation of plasmid-less bacteria with the plasmids
isolated from drug resistant bacteria made the transformants drug
resistant.
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