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Pharmacogenetic Study of Drug Metabolizing Enzyme CYP3A4 (Paperback)
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Pharmacogenetic Study of Drug Metabolizing Enzyme CYP3A4 (Paperback)
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Pharmacogenetics is generally regarded as the study of genetic
variation that gives rise to different responses to drugs. It may
be possible to predict therapeutic failures or severe adverse drug
reactions in individual patients by testing for important DNA
sequence variations or polymorphisms in key drug-metabolizing
enzymes, receptors, transporters, etc. In this book, we
characterized methods for genotyping CYP3A4*2, CYP3A4*4, CYP3A4*5,
CYP3A4*6, and CYP3A4*10 alleles among Bangladeshi population in 70
healthy adult unrelated volunteers. Cytochrome P450 3A (CYP3A)
subfamily is responsible for the metabolism of more than 60% drugs
used by the human including clinically important drugs like
nifedipine, cyclosporine, erythromycin, midazolam, triazolam,
digitoxin, lidocaine, and quinine etc. Venous blood samples were
collected from 70 healthy Bangladeshi volunteers. Genomic DNA was
extracted from these blood samples and PCR-RFLP analysis was
employed to genotype important alleles of CYP3A4. CYP3A4*2,
CYP3A4*4, CYP3A4*5, CYP3A4*6, and CYP3A4*10 alleles were found to
be absent in Bangladeshi population, which are common in other
ethnic groups
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