Extrasynaptic GABAA Receptors (Hardcover, 2014 ed.)

GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed "tonic" inhibition, has been described. Whereas synaptic GABAA receptors underlie classical "phasic" GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes.

General

Imprint:	Springer-Verlag New York
Country of origin:	United States
Series:	The Receptors, 27
Release date:	September 2014
First published:	2014
Editors:	Adam C. Errington • Giuseppe Di Giovanni • Vincenzo Crunelli
Dimensions:	235 x 155 x 19mm (L x W x T)
Format:	Hardcover
Pages:	295
Edition:	2014 ed.
ISBN-13:	978-1-4939-1425-8
Categories:	Books > Medicine > Clinical & internal medicine > Neurology & clinical neurophysiology Books > Medicine > Other branches of medicine > Pharmacology > General Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Neurosciences
LSN:	1-4939-1425-1
Barcode:	9781493914258

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