The underlying theme of this doctoral thesis was To evaluate the
role of genetic aberrations in different signal transducing
molecules of important signal transduction pathways that are
involved in the development and progression of CRC in Kashmiri
population. To assess the possible association between the genetic
aberrations of the signal transducing molecules and various life
style factors that are likely to lead to the development and
progression of colorectal cancer. To observe the significance of
multistep model of CRC carcinogenesis in explaining the CRC
carcinogenesis in our Kashmiri population. After assessing the
various signal transducing molecules for genetic aberrations we
found that the multi-step model of CRC carcinogenesis holds well in
explaining the CRC tumorigenesis in our Kashmiri population but
with a slight difference in manner and frequency of genetic
aberrations of key tumor suppressor genes and oncogenes.
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