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Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins
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Periostin (Hardcover, 1st ed. 2019)
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Periostin (Hardcover, 1st ed. 2019)
Series: Advances in Experimental Medicine and Biology, 1132
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This book provides a comprehensive and up-to-date review of current
understanding of periostin and its importance for human health and
disease. Periostin is a secretory matricellular protein that has
been revealed to play key roles in fibrillogenesis and cell
migration, including metastasis of cancer cells. The production of
periostin is upregulated during fibrotic responses and the
mechanisms by which it promotes fibrosis have become a focus of
interest owing to the potential clinical benefit to be derived from
periostin blockade. In this book, readers will find coverage of all
aspects, from the basic properties of periostin and its function as
a scaffold for assembly of extracellular proteins through to its
roles in bone and tissue regeneration, tumorigenesis, myocardial
infarction, inflammatory and immune system disorders, and other
diseases. Readers will also find the latest information on
functions of periostin related to stemness and the application of
periostin as a biomarker. It is hoped that the detailed knowledge
of periostin and its pathobiological significance provided in this
book will aid in the search for effective treatments for currently
incurable diseases.
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