Male infertility is a multifactorial syndrome encompassing a wide
variety of disorders. In more than half of infertile men, the cause
of their infertility is mysterious (idiopathic) and could be
congenital or acquired. The causes are known in less than half of
these cases, out of which genetic or inherited disease and specific
abnormalities in the Y chromosome are major factors. About 10-20
percent of males presenting without sperm in the ejaculate carry a
deletion of the Y chromosome Male genetic factor of infertility
accounts for about half the cases of couple infertility and in
around 50% of cases its etiology remains unknown. Molecular genetic
techniques have unveiled a number of etiopathogenetic factors,
including microdeletions of the Yq. Y chromosome microdeletions
removing the AZoospermia Factor (AZF) regions are the most frequent
molecular genetic causes of oligo/azoospermia).
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