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Drugs as Tools in Neurotransmitter Research (Paperback, Softcover reprint of the original 1st ed. 1989)
Loot Price: R4,290
Discovery Miles 42 900
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Drugs as Tools in Neurotransmitter Research (Paperback, Softcover reprint of the original 1st ed. 1989)
Series: Neuromethods, 12
Expected to ship within 10 - 15 working days
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Serendipitous discovery has played an important role m the
identification of physiological mechanisms in central and peri-
eral neurotransmission. In many cases, the subsequent followup of
these discoveries has been substantially aided by previouslyiden-
fied natural substances that interfered with these mechanisms. The
site of neuromuscular blockade produced by curare extracts, for
example, was shown in the 1850s by Claude Bernard, and Sir Henry H.
Dale m 1906 discovered the reversal of the pressor effects of
adrenal extracts by ergot alkaloids. These findings were the first
clues that led eventually to the definition of mcotinic cholinergic
receptors and the present classification of adrenergic receptors.
In the 1950s many discoveries, including the identification of the
catecholamines and 5-hydroxytryptamine in the central n- vous
system, followed by the development of specific sensitive
biochemical and histochemical methods and the introduction of
modern psychotropic drugs led to our increased understanding of
chemical transmission and the formulation of theories that attempt
to explain the causes of some mental disorders. The finding that
hydroxylated derivatives of noradrenaline and- hydroxytryptamine
are readily taken up by catecholaminergic or serotonergic neurons,
and that this is followed by poisoning and death of the cell,
encouraged the use of these compounds for the mapping of central
and peripheral catecholamine or- hydroxytryptamine systems, and the
mvestigation of the re- vance of these pathways to receptor
regulation or behavioral - sponses.
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