A cutting-edge review of the important issues underlying the
therapeutic use of nucleic acid-mediated gene silencing. Topics
range from basic methodology and delivery to targeting and clinical
targets. The authors thoroughly explain the latest developments in
RNA biology, as well as the underpinnings of RNA interference,
oligodeoxynucleotide delivery into cells, and strategies for
targeting these molecules to accessible regions within the mRNA.
They also provide some examples of how these new therapeutic
compounds are being used clinically.
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