Over the past decade, significant progress has been made in the
theory and applications of pharmacodynamics of antimicrobial
agents. On the basis of pharmacokinetic-pharmacodynamic modeling
concepts it has become possible to describe and predict the time
course of antimicrobial effects under normal and pathophysiological
conditions. The study of pharmacokinetic-pharmacodynamic
relationships can be of considerable value in understanding drug
action, defining optimal dosing regimens, and in making predictions
under new or changing pre-clinical and clinical circumstances. Not
surprisingly, pharmacokinetic-pharmacodynamic modeling concepts are
increasingly applied in both basic and clinical research as well as
in drug development.
The book will be designed as a reference on the application of
pharmacokinetic-pharmacodynamic principles for the optimization of
antimicrobial therapy, namely pharmacotherapy, and infectious
diseases. The reader will be introduced to various aspects of the
fundamentals of antimicrobial pharmacodynamics, the integration of
pharmacokinetics with pharmacodynamics for all major classes of
antibiotics, and the translation of in vitro and animal model data
to basic research and clinical situations in humans.
General
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