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Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins
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Poly(ADP-Ribose) Polymerase - Methods and Protocols (Hardcover, 2nd ed. 2017)
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Poly(ADP-Ribose) Polymerase - Methods and Protocols (Hardcover, 2nd ed. 2017)
Series: Methods in Molecular Biology, 1608
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This book presents multiple new and classical methods for studying
the vital poly-ADP-ribose (pADPr) pathway. Beginning with
techniques for the detection and quantification of the product of
poly(ADP-ribose) polymerase (PARP) enzymatic activity and detection
of variation in pADPr production during the cell cycle, the volume
continues with sections on the identification of pADPr protein
acceptors, methods focusing on studying molecular mechanisms of
PARP functions in eukaryotic cells, particularly those involved in
control of DNA repair and oxidative stress, as well as in
expression regulation, approaches to the in vitro reconstitution of
PARP-1 interaction with chromatin, the development and testing of
small molecule PARP inhibitors, and the functions of understudied
members of PARP family. Written for the highly successful Methods
in Molecular Biology series, chapters include introductions to
their respective topics, lists of the necessary materials and
reagents, step-by-step, readily reproducible laboratory protocols,
and tips on troubleshooting and avoiding known pitfalls.
Authoritative and practical, Poly(ADP-Ribose) Polymerase: Methods
and Protocols, Second Edition serves as an ideal companion to the
first edition for scientists whose investigations involve this
important pathway. The chapter 'Identifying and Validating
Tankyrase Binders and Substrates: A Candidate Approach' is
published open access under a CC BY 4.0 license.
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