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Books > Science & Mathematics > Biology, life sciences > Molecular biology
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The Comet Assay in Toxicology (Hardcover)
Loot Price: R4,798
Discovery Miles 47 980
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The Comet Assay in Toxicology (Hardcover)
Series: Issues in Toxicology, Volume 5
Expected to ship within 10 - 15 working days
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The vast number of chemicals existing or being added into the
environment, have globally aroused great concern regarding their
adverse effects in human population. Development and validation of
sensitive and better test systems which can assess the adverse
effects of chemicals at an early stage for intervention strategies
to be implemented in time is currently in progress. This book
documents the latest research and showcases the versatile,
state-of-the-art technique - the Comet assay - in the field of
modern toxicology. The assay is a simple, sensitive rapid and
visual technique for the quantitative and qualitative assessment of
DNA damage in single cells. The Comet Assay in Toxicology is the
first book of its kind to be devoted exclusively to the Comet assay
and its applications as an important tool in modern toxicology.
This multi-author book will serve as both a reference and a guide
to investigations in the biomedical, biochemical and pharmaceutical
sciences. Written by investigators from the fields of genetic
toxicology and human epidemiology, the authors have first-hand
knowledge from their chosen sub-specialities and are active
contributors to the peer-reviewed scientific literature. The book
is divided into five major sections, reflecting the range of
interest in the exploitation of this assay. The book's scope begins
with an introduction section reviewing its genesis for those new to
the technique and the current knowledge of the various fields in
which it finds wide acceptance. This section sets the scene by
explaining why the assay has become the most sensitive and sought
after assay in modern toxicology. Next is a whole section that
considers various procedures being followed to assess different
types of DNA damage in various cell types and is contributed by
experts in the respective fields. The third section puts together
the specific applications of the assay in the diverse fields
ranging from genetic toxicity testing to human monitoring, and
environmental toxicology. The fourth section consists of the
guidelines and recommendations for the conduct of the assay in in
vitro and in vivo systems, based on the recommendations of the
International Workgroups on genotoxicity test procedures. Finally,
the book draws to a close with an assessment of the statistics used
for the understanding of the data generated by the assay. This is a
unique reference book as it provides the scientific community with
the advances in Comet assay as well as its applications. It also
incorporates a detailed section with instant and comprehensive
information on the procedure of the assay and the latest protocols
being used worldwide as well as statistical analyses to be
followed. The book is aimed at students as well as scientists in
the area of molecular epidemiology and genetic toxicology.
General
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