This innovative book presents an original account of the principles
of conformational theory. It has a strong focus on computational
methodologies for conformational space exploration. By revisiting
basic conformational conventions, considering experimental results
which are often misinterpreted by organic chemists, and
qualitatively analyzing the potential energy surface, the book
helps non-experts to understand molecular flexibility at the level
required in contemporary research.The book shows synthetic organic
chemists how to perform successful conformational studies using
widespread calculation packages ('click computational chemistry')
instead of being misguided by textbook-based conformational
analysis. The monograph actually offers to synthetic chemists a new
research tool that can significantly upgrade their ability to
predict, or at least explain, regioselectivity and
stereoselectivity in their own reactions.
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