A cutting-edge review of how derangements in the hormonal and
growth factor mechanisms controlling normal mammary development
lead to breast cancer. Drawing on the multidisciplinary expertise
of leading authorities, the book highlights the roles of oncogenes
and tumor suppressor genes, spelling out the importance of
autocrine/paracrine loops (e.g., stromal epithelial interactions)
in supporting breast cancer cell proliferation and the progression
to hormone independence. The book's many prominent contributors
also illuminate significant recent advances in the biochemistry and
physiology of hormone receptors and review the state-of -the-art in
the endocrine therapy of breast cancer. Endocrinology of Breast
Cancer provides a unique integrated overview of the most
significant basic and clinical developments concerning the hormonal
aspects of breast cancer.
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