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Reactive Oxygen Species, Lipid Peroxidation & Protein Oxidation (Hardcover)
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Reactive Oxygen Species, Lipid Peroxidation & Protein Oxidation (Hardcover)
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Many studies have shown that free radical damage and lipid
peroxidation increase as a function of the degree of unsaturation
of the fatty acids present in the phospholipids of biological
membranes. Membrane phospholipids are particularly susceptible to
oxidation not only because of their highly polyunsaturated fatty
acid content but also because of their association in the cell
membrane with non-enzymatic and enzymatic systems capable of
generating pro-oxidative-free radical species. There are two broad
outcomes to lipid peroxidation: structural damage to membranes and
generation of secondary products. Membrane damage derives from the
generation of fragmented fatty acyl chains, lipidlipid cross-links,
lipidprotein cross-links and endocyclisation to produce
isoprostanes and neuroprostanes. These processes combine to produce
changes in the biophysical properties of membranes that can have
profound effects on the activity of membrane-bound proteins. The
consequence of peroxidation of unsaturated fatty acids is severe:
damage of membranes function, enzymatic inactivation, toxic effects
on the cellular division, etc. This new book presents and discusses
current research on oxidative stress, and lipid oxidation
non-inhibited and inhibited; assessment of oxidative balance in the
lipo- and hydro-philic cellular environment in biological systems;
mass spectrometry detection of protein modification by
cross-reaction with lipid peroxidation products; diagonal gel
electrophoretic analysis of protein disulfides: principles and
applications. Other chapters describe: heavy metals exposure and
cells oxidative damage; biodegradation of metallic biomaterials:
its relation with the generation of reactive oxygen species;
Oxidative modifications of proteins in the aging heart; role of
reactive oxygen species as signalling molecules involved in the
regulation of physiological processes of the nervous system;
oxidative stress in diabetes and hypertension treated with
alternative therapy of medicinal plants; impairment of redox
homeostasis of tissue damage in inborn errors of metabolism with
intoxication: insights from human and animal studies and finally
lipid peroxidation of phospholipids in the vertebrate retina or in
liposomes made of retinal lipids: similarities and differences are
described.
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