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Tumor Necrosis Factor - Methods and Protocols (Hardcover, 2004 ed.)
Loot Price: R2,953
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Tumor Necrosis Factor - Methods and Protocols (Hardcover, 2004 ed.)
Series: Methods in Molecular Medicine, 98
Expected to ship within 10 - 15 working days
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Tumor necrosis factor (TNF)-? is a pleiotropic cytokine involved in
a va- ety of physiological and pathological processes. After
initial discovery of its ability to induce cell death and animal
cachexia, it was soon realized that this cytokine played pivotal
roles in the regulation of homeostasis and inflam- tory-immune
responses. This led to an explosion of interest in basic and tra-
lational research activities on the role of TNF in many diseases,
such as cancer, septic shock, rheumatoid arthritis, and infectious
diseases of the central n- vous system. Because of its potential
therapeutic value, many academic and industrial research groups
have worked to discover compounds that can block its activity.
These studies have led to the approval of anti-TNF antibodies and
soluble TNF receptors for the therapy of rheumatoid arthritis and
Crohn's d- ease. TNF also can be an attractive anticancer agent
capable of damaging tum- associated vessels and of inducing tumor
necrosis in patients. The unique properties of TNF have led to its
registration as a drug for locoregional tre- ment of sarcomas of
the extremities, and stimulated many preclinical studies aimed at
improving its therapeutic index for systemic use. Tumor Necrosis
Factor: Methods and Protocols provides an overview of basic and
translational research along with a series of practical procedures
on TNF production, characterization, mutagenesis, detection in
biological spe- mens, as well as several in vitro assays and animal
models for studying the role of TNF in various diseases.
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