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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
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The Link Between Inflammation and Cancer - Wounds that do not heal (Hardcover, 2006 ed.)
Loot Price: R4,597
Discovery Miles 45 970
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The Link Between Inflammation and Cancer - Wounds that do not heal (Hardcover, 2006 ed.)
Series: Cancer Treatment and Research, 130
Expected to ship within 10 - 15 working days
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A link between inflammation and cancer has been established many
years ago, yet it is only recently that the potential significance
of this connection has become apparent. Although several examples
of chronic inflammatory conditions, often induced by persistent
irritation and/or infection, developing into cancer have been known
for some time, there has been a notable resistance to contemplate
the possibility that this association may apply in a causative way
to other cancers. Examples for such progression from chronic
inflammation to cancer are colon carcinoma developing with
increased frequency in patients with ulcerative colitis, and the
increased incidence of bladder cancer in patients suffering from
chronic Schistosoma infection. Inflammation and cancer have been
recognized to be linked in another context for many years, i.e.,
with regards to pathologies resembling chronic lacerations or
'wounds that do not heal.' More recently, the immunology of wound
healing has given us clues as to the mechanistic link between
inflammation and cancer, in as much as wounds and chronic
inflammation turn off local cell-mediated immune responses and
switch on growth factor release as well the growth of new blood
vessels - angiogenesis. Both of these are features of most types of
tumours, which suggest that tumours may require an immunologically
shielded milieu and a growth factor-rich environment.
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