This book compiles the theoritical studies done on cyclic peptidic
and peptidomimetic compounds.Ab initio 'Hartree Fock Molecuclar
Orbital' calculations have been done on cyclic compounds to
determine their potential to play role as ion and drug
carriers.Role of substituents and backbone type have been
thoroughly studied to understand properties which facilitate ion
selectivity and potential to cross Blood Brain Barrier.Lead
compound has been suggested to selectively remove zinc ions from
brain so as to reduce plaque formation responsible for Alzheimer's
disease.Also, a suitable carrier has been suggested for extensively
used drug, Levodopa used for treatment of patients suffering from
Parkinson's disease. The work with cyclic compounds is extended to
find out possibilities of self aggregation. Properties of cyclic
compounds to self aggregate/assemble lead to formation of hollow
tubular structures in nanorange.They also showed probability of
carrying drugs inside them in an efficient manner without forming
covalent bonds. This study reveals that cyclic compounds are very
interesting systems with wide variety of applications and can be
modified intelligently according to one's needs
General
Imprint: |
Lap Lambert Academic Publishing
|
Country of origin: |
Germany |
Release date: |
February 2012 |
First published: |
February 2012 |
Authors: |
Antara Banerjee
|
Dimensions: |
229 x 152 x 7mm (L x W x T) |
Format: |
Paperback - Trade
|
Pages: |
116 |
ISBN-13: |
978-3-8473-0969-7 |
Categories: |
Books >
Science & Mathematics >
Chemistry >
Physical chemistry >
General
|
LSN: |
3-8473-0969-2 |
Barcode: |
9783847309697 |
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