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Myths And Verities In Protein Folding Theories (Paperback)
Loot Price: R956
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Myths And Verities In Protein Folding Theories (Paperback)
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This book tells the story of a whole field of research which went
disastrously wrong in many different directions when the wrong
tools were used and the wrong targets aimed at, to solve a
problem.It all started from the misinterpretation of Schellman's
experiments which were carried out in the mid-1950s, and which were
later encapsulated by the so-called 'Hydrogen-bond inventory
argument.' As a result, hydrogen bonding was ignored in protein
folding; along with that a whole repertoire of other possible
hydrophilic effects were not even considered. Against this
background the hydrophobic effects, as suggested by Kauzmann,
became the single most important effects in protein folding.In
addition, as a result of the misinterpretation of Anfinsen's
hypothesis, as well as misunderstanding of the Second Law, people
made futile attempts to search for the structure of proteins in the
global minimum of either the Energy, or the Gibbs Energy Landscape.
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