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The P53 Family - A Subject Collection from Cold Spring Harbor Perspectives in Biology (Hardcover)
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The P53 Family - A Subject Collection from Cold Spring Harbor Perspectives in Biology (Hardcover)
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The p53 tumor suppressor gene--the "guardian of the
genome"--protects cells against genotoxic stress but is mutated in
many cancers. It encodes one of a family of transcription factors
(p53, p63, and p73) that regulate cell proliferation,
differentiation, senescence, and cell death. Mutations in p53 allow
cells to escape normal growth controls and thereby contribute to
tumor malignancy.
Written and edited by experts in the field, this collection from
Cold Spring Harbor Perspectives in Biology provides a comprehensive
review of the functions of the p53 family. The contributors examine
the normal roles of these transcription factors, the regulatory
mechanisms that control p53 activity, and the part played by p53
mutations in tumorigenesis. They also discuss the evolution of the
p53 family, which may originally have arisen to protect the
integrity of the germ line. This collection also covers the
structure of p53 and its isoforms, model systems for analyzing p53
function, studies of p53 polymorphisms, and therapeutic approaches
aimed at targeting p53 defects in cancer.
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