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Role of CD2 and CD48 in recruitment of signaling molecules in T cells (Paperback)
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Role of CD2 and CD48 in recruitment of signaling molecules in T cells (Paperback)
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The role of lipid rafts or glycosylphosphatidylinositol (GPI)-
domains has been reported to be very important during T cell
activation via clustering important molecular players, such as
adhesion molecules, GPI-anchored proteins or signaling kinases. The
main focus of my study is to explore the role of GPI-anchored
proteins in activation of T cells. We have previously found that
the GPI-anchored molecules, CD48 and CD59 behave differentially.
Since CD2 has been shown to interact with CD48 in cis and trans
configuration, I asked whether this interaction could be
responsible for the differential behavior of CD48 and CD59. For
this purpose I used the siRNA technology and down regulated CD2 and
CD48 expression in Jurkat T cells. The knock- out cells showed
altered recruitment of Lck, a Src family kinase (SFK) member, and
LAT, a transmembrane adaptor protein (TRAP), to the TCR/CD3,
decreased IL-2 promoter activity and decreased calcium flux as
compared with the normal cells. Thus, these results show that CD2
and CD48 are not only important for recruitment of Lck and LAT but
that they also interplay for association of these molecules and
proper signal transduction.
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