Cell Separation - Fundamentals, Analytical and Preparative Methods (Hardcover, 2007 ed.)

Cell separation, which was once limited to merely being a basic technique for fractionating different cell populations, has come a long way in the last two decades. New, advanced and more speci?c and selective techniques have emerged as the demand for isolating a speci?c cell type for various biological applications has increased. Ef?cient and cost-effective techniques for fr- tionation and isolation of target cell types are necessary to provide pure cell populations for diagnostics, biotechnological and biomedical applications. One can see a considerable need, both in biomedical research and in di- nostic medicine, for the speci?c separation of a discrete population of cells from a mixture. For example, in the ?eld of tissue engineering, isolation of stemcellsfromtissuesororgansisofparticularlygreatimportance.Moreover, understanding cell developmental pathways becomes increasingly signi?cant as diagnosis and treatment of diseases turns more to the molecular level. The diagnosis of cell-related diseases requires methods of detection, isolation and theanalysisofindividualcells,regardlessoftheirrelativecontentinthetissue. Since cell-based therapies now turn towards more realistic medical options, developing an effective separation system for large-scale cell separation has becomechallengingresearchgoalforcellbiologistsandbiotechnologists.The ideal technique should provide in a short time a good yield of cells with high puritywhile maintaining cellfunction.Despite the growingneed formethods to separate cells into cell subpopulations, the existing cell-separation te- niques stillhave somelimitations when the desired degree ofperformance on apreparativescaleisrequired.Wewillseemoreresearchfocusinthisdirection in the future. The traditional techniques of micro?ltration, ultra?ltration and ultrac- trifugation, which exploit differences in cell size, shape and density, have remainedtheworkhorsesdespitelowspeci?cityandproblemswithscalingup.

General

Imprint:	Springer-Verlag
Country of origin:	Germany
Series:	Advances in Biochemical Engineering/Biotechnology, 106
Release date:	November 2007
First published:	2007
Editors:	Ashok Kumar • Igor Yu Galaev • Bo Mattiasson
Dimensions:	235 x 155 x 15mm (L x W x T)
Format:	Hardcover
Pages:	203
Edition:	2007 ed.
ISBN-13:	978-3-540-75262-2
Categories:	Books > Professional & Technical > Biochemical engineering > Biotechnology > General Promotions
LSN:	3-540-75262-5
Barcode:	9783540752622

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