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Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins
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Chemokines - Methods and Protocols (Paperback, Softcover reprint of the original 1st ed. 2013)
Loot Price: R2,702
Discovery Miles 27 020
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Chemokines - Methods and Protocols (Paperback, Softcover reprint of the original 1st ed. 2013)
Series: Methods in Molecular Biology, 1013
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Chemokines constitute a large family of structurally similar
cytokines that contain a signature of conserved cysteine residues
joined by disulfide bridges. Binding of chemokines to specific G
protein-coupled receptors followed by downstream signaling defines
their biological function. Initially, chemoattraction was the key
function linked to chemokines/chemokine receptors; however, in
recent years, it has become clear that chemokine ligand-receptor
interactions can also modulate cellular activation, survival, and
proliferation, among other functions in homeostatic and diseased
states. Importantly, major advances in our understanding of
chemokine biology have led to chemokine receptors becoming specific
therapeutic targets with great potential. In Chemokines: Methods
and Protocols, expert researchers provide practical information
regarding experimental models and state of the art protocols used
to delineate chemokine/chemokine receptor function and their
applications in health and disease. Written in the highly
successful Methods in Molecular Biology series format, chapters
include introductions to their respective topics, lists of the
necessary materials and reagents, step-by-step, readily
reproducible laboratory protocols, and tips on troubleshooting and
avoiding known pitfalls. Practical and easy to use, Chemokines:
Methods and Protocols aims to reveal key protocols of functional
and descriptive chemokine ligand/receptor assays that will be of
practical significance to graduate students, post-doctoral fellows,
trainees, and researchers in academia and industry.
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