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The Alkali Metal Ions: Their Role for Life (Hardcover, 1st ed. 2016)
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The Alkali Metal Ions: Their Role for Life (Hardcover, 1st ed. 2016)
Series: Metal Ions in Life Sciences, 16
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MILS-16 provides an up-to-date review of the impact of alkali metal
ions on life. Their bioinorganic chemistry and analytical
determination, the solid state structures of bio-ligand complexes
and the properties of alkali metal ions in solution in the context
of all kinds of biologically relevant ligands are covered, this
includes proteins (enzymes) and nucleic acids (G-quadruplexes).
Minerals containing sodium (Na+) and potassium (K+) are abundant in
the Earth's crust, making Na+ and K+ easily available. In contrast,
the alkali elements lithium (Li+), rubidium, and cesium are rare
and the radioactive francium occurs only in traces. Since the
intra- and extracellular, as well as the compartmental
concentrations of Na+ and K+ differ significantly, homeostasis and
active transport of these ions are important; this involves
transporters/carriers and pore-forming ion channel proteins.
Systems like Na+/K+-ATPases, H+/K+-ATPases or Na+/H+ antiporters
are thoroughly discussed. The role of K+ in photosynthesis and the
role of Na+ in charging the "battery of life" are pointed out.
Also, the relationships between alkali metal ions and diseases
(e.g., Parkinson or traumatic brain injury) are covered and the
relevance of Li+ salts in medicine (pharmacology and mechanism) is
reviewed. This and more is treated in an authoritative and timely
manner in the 16 stimulating chapters of Volume 16, The Alkali
Metal Ions: Their Role for Life, which are written by 44
internationally recognized experts from 12 nations. The impact of
this vibrant research area is manifested in nearly 3000 references,
over 30 tables and more than 150 illustrations (two thirds in
color). MILS-16 also provides excellent information for teaching.
Astrid Sigel, Helmut Sigel, and Roland K. O. Sigel have
long-standing interests in Biological Inorganic Chemistry. Their
research focuses on metal ion interactions with nucleotides and
nucleic acids and on related topics. They edited previously 44
volumes in the series Metal Ions in Biological Systems.
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