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Books > Professional & Technical > Biochemical engineering
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Cationic Polymers Based Non-Viral Gene Carriers (Paperback)
Loot Price: R1,577
Discovery Miles 15 770
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Cationic Polymers Based Non-Viral Gene Carriers (Paperback)
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Nucleic acids-based next generation biopharmaceuticals (i.e.,
oligonucleotides, siRNA) are potential therapeutic agents have
ability to cope with various incurable diseases. However, several
biological barriers present a challenge for efficient gene
delivery. Inception of nanotechnology now offer numerous non-viral
vectors that have been fabricated and found capable of transmitting
the biopharmaceuticals into the cell and even into specific
subcellular compartments like mitochondria. This book illustrates
novel chemically modified polyallylamine and polyethylenimine based
nano- vectors for enhanced gene delivery. Modification of these
polymers using imidazolyl and polysaccharides such as hyaluronic
acid, chondroitin sulfate and heparin not only improve cytotoxicity
index but also provides site-specificity for cell-type specific
gene delivery. Incorporation of targeting moiety minimizes the
chance of potential adverse effects and also reduces the amount the
amount of dose required to achieve desired therapeutic effects.
Recent developments in formulation of efficient drug carriers
showed potential to develop gene therapy again diseases like
cancer.
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