This volume evaluates the clinical patterns of resistance to
sorafenib, the impact of trial design in the second-line setting
and the current gold standard to define radiological resistance;
describes the molecular mechanisms responsible for treatment
resistance in HCC patients, including components of the immune
system and tumor microenvironment; determines the role of the
cancer stem cell phenotype in resistance; reviews the experimental
models to study resistance; and addresses new approaches to
overcome resistance to sorafenib, using successful examples from
other malignancies.
General
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