Inflammation and Demyelination in the Central Nervous System - International Congress of Neuropathology, Vienna, September 5-10, 1982 (Paperback)

The present report, compares two murine models of virus induced chronic relapsing demyelination. MHV-induced demyelination in the BALB/c mouse results from the direct virus mediated cytolysis of oligodendrocytes. Extensive remyelination by oligodendrocytes is noted. Recurrent demyel- ination occurs in small areas. Infectious virus persists and 34 Fig. 2: Demyelination in SJL/J mice infected with TMEV. A) Multifocal areas of perivascular demyelination in the spinal cord (110 days post infection). Para- phenylene diamine stain. X 250. B) Perivascular inflammatory infiltration within the white matter of the spinal cord (22 days post infec- tion). Paraphenylene diamine stain. X600. C) Localization of TMEV associated antigen in the cytoplasm of oligodendrocytes (45 days post infec- tion). Vibratome section stained with the peroxidase-anti peroxidase technique. X 400. D) Immunoperoxidase staining of viral antigen within inner and outer loops of an oligodendrocyte (45 days post infectin) X 60,000. E) Longitudinal section showing viral antigen within Schmidt-Lanterman incisures (80 days post infection). X 49,000. viral antigens are localized within oligodendrocytes and their processes. TMEV-induced demyelination in SJL/J mice is asso- ciated with perivascular inflammatory infilrates and is dimin- ished by immunosuppressive measures. Remyelination by oligo- dendrocytes is delayed and incomplete. Chronic demyelination is widespread and associated with perivascular inflammatory infiltrates. The virus persists and viral antigen is local- ized within oligodendrocytes.

General

Imprint:	Springer-Verlag
Country of origin:	Germany
Series:	Acta Neuropathologica Supplementa, 9
Release date:	August 1983
First published:	1983
Editors:	B.H. Waksman • T. Yonezawa • H. Lassmann
Dimensions:	244 x 170 x 5mm (L x W x T)
Format:	Paperback
Pages:	94
ISBN-13:	978-3-540-12420-7
Categories:	Books > Medicine > Other branches of medicine > Pathology > Gross pathology Books > Medicine > Clinical & internal medicine > Diseases & disorders > Infectious & contagious diseases > General Promotions
LSN:	3-540-12420-9
Barcode:	9783540124207

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