The Major Histocompatibility Complex (MHC) was discovered as a con
sequence of the chronic problem encountered by cancer biologists in
the early years of this century: the failure to maintain tumor
lines by serial passage in outbred mice. A number of observations
pointed to genetic similarity being a prerequisite for successful
transplantation and they were incorporated into a genetic theory of
transplantation by C.C. Little. This prompted scientists like
Little to initiate breeding experiments designed to test his
hypothesis and produce genetically identical mice which would
permit the growth of trans planted tumors. Most inbred strains of
mice commonly used in immunology derive from those efforts.
Transplantation of normal tissues obeyed the same rules found for
malignant tissues and rejection was shown to be an immunological
phenomenon. G.D. Snell showed that a single genetic locus
determined rapid rejection of skin grafts. This was initially
called the Major Histocompatibility Locus but was subsequently
shown to include many functionally related genes and renamed the
Major Histocompatibility Complex (MHC). In mouse this is the H-2
complex and man the HLA complex. During this same period P.A."
General
| Imprint: |
Springer
|
| Country of origin: |
Netherlands |
| Series: |
World Crop Series |
| Release date: |
November 2013 |
| First published: |
1982 |
| Editors: |
B. Parham
|
| Dimensions: |
229 x 152 x 14mm (L x W x T) |
| Format: |
Paperback
|
| Pages: |
246 |
| Edition: |
Softcover reprint of the original 1st ed. 1982 |
| ISBN-13: |
978-9400958968 |
| Categories: |
Books >
Reference & Interdisciplinary >
Interdisciplinary studies >
General
Promotions
|
| LSN: |
940095896X |
| Barcode: |
9789400958968 |
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