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Books > Medicine > Pre-clinical medicine: basic sciences > Anatomy
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Hybridomas and Cellular Immortality (Paperback, Softcover reprint of the original 1st ed. 1983)
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Hybridomas and Cellular Immortality (Paperback, Softcover reprint of the original 1st ed. 1983)
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The ability to "immortalize" immunologically-useful cells by
hybridization with a unique cancer cell has revolutionized
serological studies and has revealed new potential applications in
all fields of biological sciences. This volume presents the studies
from a highly successful national symposium on Hybridomas and
Cellular Immortality held November 1981 in Houston, Texas. The
individual chapters exhibit the diversity of topics discussed
during the meeting. These include emphasis on the origin of
antibody diversity, Band T lymphocyte differentiation, applications
of monoclonal antibodies in studies of histocompatibility, tumor,
and viral antigens, plus the use of somatic cell hybridizations for
studying T cell products. Three papers focus on the emerging
methodologies of in vitro primary immunizations for both humoral
and cell-mediated immunities, relevant for coupling with hybridoma
technology. There is a useful mix of general (methods) and specific
(applications) chapters. A unique aspect of the book is the
presentation of both recent research findings with concise
descriptions of the state of the art methodologies. It is
anticipated that this work will be of interest to a wide audience
of practioners in biomedical research. Hopefully, the information
contained will foster new and imagi native ideas in hybridoma
applications. Baldwin H. Tom, Ph.D. James P. Allison, Ph.D. vii
CONTENTS PART L INTRODUCTION TO HYBRIDOMAS 1 Somatic Cell Hybrids
and Hybridomas Baldwin H. Tom 3 1. Somatic Cell Hybrids 8
Hybridomas. * * * * * 2.
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