Improving the Therapeutic Ratio in Head and Neck Cancer provides a
complete review of current approaches to modulating therapeutic
sensitivity in head and neck cancer. It presents a broad background
of current approaches and by highlighting the potential for
clinical translational, introduces a roadmap for how to move
promising preclinical findings into the clinic. The book discusses
topics such as immunotherapy and molecularly targeted therapies in
head and neck cancer, PI3k/mTOR pathway, autophagy inhibition to
sensitize HNC to radiation and chemotherapy, TAM and Eph/Ephrin
family proteins and metabolic reprogramming to modulate therapeutic
sensitivity. Additionally, it details approaches to improve the
response to immunotherapy, and Chk1/2 inhibition in radiation and
cetuximab resistance. This book is a valuable source to head and
neck cancer researchers and advanced students, and to those
studying specific approaches in other model systems and disease
sites.
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