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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Leukocyte Integrins in the Immune System and Malignant Disease (Paperback, Softcover reprint of the original 1st ed. 1998)
Loot Price: R2,928
Discovery Miles 29 280
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Leukocyte Integrins in the Immune System and Malignant Disease (Paperback, Softcover reprint of the original 1st ed. 1998)
Series: Current Topics in Microbiology and Immunology, 231
Expected to ship within 10 - 15 working days
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Most lymphocytes recirculate throughout the body, migrating from
blood through organized lymphoid tissues such as lymph nodes (LN)
and Peyer's patches (PP), then to lymph and back to blood (GOWANS
and KNIGHT 1964). Smaller numbers of lymphocytes migrate from blood
to extranodal tissues such as pancreas and then through lymphatic
vessels to LN (MACKAY et al. 1990). An important feature of this
migration is the ability of lymphocytes to recognize and adhere to
the surface of blood vessel endothelial cells before migrating
through the vessel wall into surrounding tissue (CARLOS and HARLAN
1994; IMHOF and DUNON 1995; BUTCHER and PICKER 1996). Adhesion
interactions of vascular endothelium with lymphocytes under flow or
shear consist of at least four steps: (I) an initial transient
sticking or rolling; (2) if the lymphocytes encounter appropriate
activating or chemotactic factors in the local environment, rolling
may be followed by a lymphocyte activation step that then leads to;
(3) strong adhesion or sticking that may be followed by; (4) lym
phocyte diapedesis into tissue (BUTCHER 1991; SHIMUZU et al. 1992;
SPRINGER 1994; BARGATZE et al. 1995). Specific lymphocyte and
endothelial adhesion molecules (AM) are involved in each step of
this "adhesion cascade" (reviewed in CARLOS and HARLAN 1994; IMHOF
and DUNON 1995; BUTCHER and PICKER 1996). This allows lymphocyte
migration to be controlled at several different steps, leading to a
combinatorial increase in specificity and sensitivity."
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