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Chronic Psychological Stress and Aging (Paperback)
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Chronic Psychological Stress and Aging (Paperback)
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Total price: R1,305
Discovery Miles: 13 050
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Psychological stress has extreme adverse consequences on health.
However, the molecular mechanisms that mediate and accelerate the
process of aging due to stress hormone are not well defined. This
review has focused on diverse molecular paths that come out in
response to chronic psychological stress via releasing of excessive
glucocorticoids (GCs), involved in the aging process. GCs suppress
transcription of nuclear cell adhesion molecules which impair
synaptic plasticity, memory formation, and cognitive ability.
Again, GCs promote muscle atrophy by means of motivating ubiquitin
proteasome system and can repress muscle protein synthesis by
inhibition of PI3-kinase/Akt pathway. GCs also inhibit
interleukin-2 synthesis through suppressing T cell receptor signal
that leads to loss of T cell activation, proliferation, and B-cell
activation. Moreover, GCs increase the expression of collagenase-3,
RANK ligand, and colony stimulating factor-1 that induce bone
resorption. In general, stress-induced GCs can play causal role for
aging and age-related disorders.
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