Atherosclerosis is a disease that causes medium-size and larger
blood vessels in the body to harden and narrow which is not a
clinical symptoms but it is the ultimate stage of any types of
coronary heart disease like stroke, heart attack, myocardial
infarction, paralysis and so on. In recent decades, there has been
increasing interest in exploring the relationship between
psychological stress and various health conditions. Extensive
studies support that behavioral and psychological factors
contribute significantly to the development and progression of
atherosclerosis. Psychological factors, specifically depression,
anxiety, personality factors, social isolation, and chronic and
sub-acute life stress, are known to be related to the risk of heart
disease. This spurred on the relentless effort to explore how
behaviour and biological systems could interact in the endeavour to
uncover more mysteries of the human body. This review addresses the
biomolecular mechanism of understanding the role of chronic
psychological stressors on the immune system and development of
atherosclerosis as well as established the relationship between the
chronic psychological stress and the atherosclerosis.
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