With the successful mapping of the human genome, we have entered an
age of unprecedented opportunity in which researchers are beginning
to apply this vast repository of knowledge to the treatment of
human disease. Gene-profiling technologies and the concept of
individualized medicine are leading to the development of drugs
with enhanced specificity. This promises to lead to more effective
treatment of diseases with reduced risk of side effects.
Gene Profiling in Drug Design provides insights from leaders in
the pure sciences, biotechnology, and other arenas. It emphasizes
the science that underpins gene profiling and drug development, and
also includes clinical and ethical perspectives from experts in
those fields. These explore the broadest health and social
implications for this exciting field of science and discovery.
The book begins with a discussion of the future clinical impact
of genetic diagnosis and gene-based drug therapies. Virally encoded
MicroRNA is reviewed, as well as the development of
gene-profile-responsive antisense agents. Gene profiles are studied
with respect to drug development and cancer research. RNA viruses
and RNA-based drugs are also examined. Finally, ethical
considerations of this groundbreaking technology are explored.
The information presented in this volume provides readers with a
greater understanding of the processes and technologies in
gene-profile based drug design. Technologies are discussed in
sufficient detail so that drug developers can use the book as a
general desk reference. It also provides physicians with an
important survey of emerging technologies.
This book is edited by Brett A. Lidbury and Suresh Mahalingam,
noted scientistsfrom the Centre for Biomolecular and Chemical
Sciences at the University of Canberra in Australia. They bring
together the wisdom of numerous experts to discuss the powerful
ways that these new genetic technologies can save lives and improve
health.
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