While one marvels at the DNA generated by the Human Genome Project,
perhaps just as significant and fascinating is the development of
the amazing analytical technology that has permitted us entry into
the genomic era and a whole new level of scientific understanding.
Analytical Techniques in DNA Sequencing takes a look at the
various DNA sequencing techniques that were developed and put to
use during and after the Human Genome Project. Nunnally makes a
special effort to trace the development of this branch of research
since the early days of radioisotope sequencing. Special attention
is paid to the breakthrough Sanger Method (1977), as well as to
several other techniques that improved the accuracy, improved the
detection limits, and in a variety of ways dramatically reduced the
time needed to generate a DNA sequence.
This comprehensive volume describes the improvements in DNA
separation based on advanced capillary electrophoresis and
microchip sequencing. It also looks at the use ofmass spectrometry
and single molecule detection, and takes an in-depth look at the
use of various fluorescence methods for the detection of sequencing
fragments. One chapter is dedicated to chip-based microfabricated
sequencing systems, which could well be the future of DNA
sequencing.
The book's ten chapters, authored by a variety of leading
experts in the field, include many of the far-reaching applications
of DNA sequencing. Entire chapters are dedicated to DNA typing for
forensics, a reevaluation of ancient DNA, and genome analysis.
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