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Epithelia - Advances in Cell Physiology and Cell Culture (Paperback, Softcover reprint of the original 1st ed. 1990)
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Epithelia - Advances in Cell Physiology and Cell Culture (Paperback, Softcover reprint of the original 1st ed. 1990)
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Epithelial cells probably constitute the most diverse group of
cells found in the body. In addition to serving as interfaces
between external and internal environments, their functions include
ion and fluid secretion and reabsorp tion, protein exocytosis,
hormone secretion, recognition, surface protection and the control
of ciliary movement. By their very exposure on the surfaces of the
body, epithelial cells are subjected to wide-ranging assault, by
micro organisms and by chemical and physical forces. They are the
targets for abrasion, infection and malignant transformation. Some
epithelial cells show altered behaviour in inherited syndromes,
such as cystic fibrosis, characterized by serious pancreatic and
pulmonary disease. In view of the importance of epithelia and the
fact that their function can be altered by environmental and
inherited factors, they are the subject of intensive research,
particularly so in the case of cancer where most tumours are of
epithelial origin. The use of animal tissues in epithelial research
continues to provide important advances and this, coupled with the
need to focus more on human tissues, has prompted a greater
research emphasis on accessible human epithelia and on the
establishment of cell cultures from animal and human sources. For
primary cell cultures and cell lines to be of value, they need to
express properties appropriate to their progenitors and relevant to
the study in progress."
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