"Homology Effects" offers contributions from an international panel
of researchers whose aim has been both to introduce newcomers to
the field of homology effects, and to bring colleagues up to date.
Topic coverage includes dosage compensation, X-inactivation,
imprinting, paramutation, homology-dependent gene silencing,
transvection, pairing-sensitive silencing, nuclear organization of
chromosomes, DNA repair, quelling, RIP, RNAi and antisense biology,
homology effects in ciliates, prion biology, and a discourse on the
evolution of gene duplications.
Advances in Genetics presents an eclectic mix of articles of use to
all human and molecular geneticists. They are written and edited by
recognized leaders in the field and make this an essential series
of books for anyone in the genetics field.
Homology, the examination of similarity due to shared common
ancestry, encompasses a fascinating class of phenomena in mammals,
plants, insects, ciliates, nematodes, fungi, and bacteria. Homology
effects concern processes that recognize homology at the level of
DNA and/or RNA, as well as at the level of protein. Their
collective history begins at the turn of the century and includes
some of the most puzzling and extraordinary observations in
biology. The volume covers phenomena that have often been
considered unusual, exceptional to the rule, and "out of the
ordinary" and, therefore, not for general study. However, it is now
becoming clear that taken together, these phenomena represent a
class of regulatory mechanisms that are widespread, as well as
exceptionally powerful.
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