Caroline HA(c)bert and a panel of key experimentalists and clinical
investigators comprehensively review the state-of-the-art in the
chemokine field, ranging from the effects of chemokines and their
receptors in retroviral infections, to their role in inflammation,
angiogenesis/angiostasis, and tumor cell biology. The book examines
in detail fifteen recently identified chemokines and elucidates the
role of chemokine function in vivo from animal experiments. Animal
models are also used to explore how chemokines operate in a variety
of chronic and acute inflammatory diseases and in noninflammatory
processes. A detailed review of the emerging role of chemokines in
viral biology is also presented, with emphasis on HIV biology and
novel therapeutic possibilities. Chemokines in Disease: Biology and
Clinical Research summarizes the rapidly expanding knowledge of a
dazzling array of chemokines and provides fresh insights into the
development of powerful new drugs for treating a wide spectrum of
diseases.
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