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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Neurosciences
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From Development to Degeneration and Regeneration of the Nervous System (Hardcover, New)
Loot Price: R3,035
Discovery Miles 30 350
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From Development to Degeneration and Regeneration of the Nervous System (Hardcover, New)
Expected to ship within 10 - 15 working days
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This book provides current information about the three areas
mentioned in the title: Neuronal Migration and Development,
Degenerative Brain Diseases, and Neural Plasticity and
Regeneration. The chapters about brain development examine the
cellular and molecular mechanisms by which neurons are generated
from the ventricular zone in the forebrain and migrate to their
destinations in the cerebral cortext. This description of cortical
development also includes a discussions of the Cajal-Retzius cell.
Another chapter provides insight about the development of another
forebrain region, the hypothalamus. The remaining chapters of this
section examine the clinical relevance of brain development in
certain disease states in humans: neural tube defects and the
normal and abnormal development of human electroencephalographic
recordings during the first year of age.
The second section on degenerative disorders of the brain begins
wtih details about the dopaminergic neurons in the substantia niger
and their loss in Parkinson's disease. Two subsequent chapters
describe changes in brain aging, including changes in the numbers
of myelinated axons. Other chapters in this section describe
important cellular and molecular changes found in Alzheimer's
disease and human epilepsy. Together, these chapters summarize much
of our current knowledge about the major molecular and cellular
changes found in several degenerative diseases of the brain.
The last section addresses the issues of brain plasticity and
regeneration in the adult brain and begins with a chapter on how
the brain's own stem cells provide newly generated neurons to the
hippocampal dentate gyrus and how these neurons become integrated
into neural circuitry. The following two chapters examine some of
the neuroplastic changes that take place in motor and sensory
cortices of awake behaving primates. The concluding two chapters
address the issue of regeneration in the injured spinal cord and
the factors that may contribute to its success.
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