The dopaminergic neurons of the ventral midbrain (mesDA neurons)
form several distinct sub-populations which are involved in
emotional control, reward behaviour and motor control. In patients
with Parkinsons Disease, the dopaminergic neurons of the substantia
nigra, pars compacta (SNpc) gradually die. One focus of research
has been to find an explanation why the SNpc neurons are more
vulnerable to cellular stress than other neuronal populations. KATP
channels consist of Sur1 or 2 and Kir6.1 or 6.2 subunits and link
the metabolic state of a cell to its membrane potential.
Hypothetically, the normal open-closed state of KATP channels might
influence cellular survival when the mesDA neurons are under
oxidative stress. In this work, I show that blocking KATP channels
in vitro by pharmaceutical means has a positive effect on cell
survival when mesDA are under oxidative stress. Conversely, forced
activation of KATP channels under these conditions leads to an
increased rate of cell death. This highlights the importance of
KATP channel function and may give a new direction in the
development of drugs targeting Parkinsons disease.
General
Imprint: |
VDM Verlag Dr. Mueller E.K.
|
Country of origin: |
Germany |
Release date: |
May 2008 |
First published: |
May 2008 |
Authors: |
Christian Scholz
|
Dimensions: |
229 x 152 x 7mm (L x W x T) |
Format: |
Paperback - Trade
|
Pages: |
132 |
ISBN-13: |
978-3-639-03219-2 |
Categories: |
Books >
Medicine >
General issues >
General
|
LSN: |
3-639-03219-5 |
Barcode: |
9783639032192 |
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