Posttranslational Modification of Proteins - Tools for Functional Proteomics (Hardcover, 2002 ed.)

Posttranslational Modifications of Proteins: Tools for Functional Proteomics is a compilation of detailed protocols needed to detect and analyze the most important co- and posttranslational modifications of proteins. Though, for reasons of simplicity not explicitly mentioned in the title, both kinds of modifications are covered, whether they occur during, or after, biosynthesis of the protein. My intention was to cover the most significant protein modifications, focusing on the fields of protein function, proteome research, and the characterization of pharmaceutical proteins. The majority of all proteins undergo co- and/or posttranslational modifications. Knowledge of these modifications is extremely important, since they may alter physical and chemical properties, folding, conformation distribution, stability, act- ity, and, consequently, function of the proteins. Moreover, the modification itself can act as an added functional group. Examples of the biological effects of protein mo- fications include: phosphorylation for signal transduction, ubiquitination for p- teolysis, attachment of fatty acids for membrane anchoring or association, glycosylation for protein half-life, targeting, cell-cell and cell-matrix interactions, and carboxylation in protein-ligand binding to name just a few. Full understanding of a specific protein structure-function relationship requires detailed information not only on its amino acid sequence, which is determined by the corresponding DNA sequence, but also on the presence and structure of protein modifications.

General

Imprint:	HumanaPress
Country of origin:	United States
Series:	Methods in Molecular Biology, 194
Release date:	April 2002
First published:	2002
Editors:	Christoph Kannicht
Dimensions:	235 x 155 x 19mm (L x W x T)
Format:	Hardcover
Pages:	322
Edition:	2002 ed.
ISBN-13:	978-0-89603-678-9
Categories:	Books > Science & Mathematics > Biology, life sciences > Molecular biology
LSN:	0-89603-678-2
Barcode:	9780896036789

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